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NATURE . COM {}

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We are analyzing https://www.nature.com/articles/nri.2017.142.

Title:
NF-κB, inflammation, immunity and cancer: coming of age | Nature Reviews Immunology
Description:
Here, Koji Taniguchi and Michael Karin discuss the key roles of the nuclear factor-κB (NF-κB) transcription factor in cancer-related inflammation and consider the potential of targeting NF-κB in different types of cancer. Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Nature.com Make Money? {💸}


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Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
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Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $42,042 to $115,616.

Keywords {🔍}

pubmed, google, scholar, cas, cancer, central, nfκb, cell, inflammation, cells, rev, immunol, nat, nature, activation, signaling, karin, role, biol, tumor, immunity, sci, res, factor, tumorigenesis, progression, metastasis, promotes, development, nuclear, function, research, immune, colorectal, foundation, stem, clin, regulation, pathway, med, pancreatic, article, tumour, stat, therapy, interleukin, science, liver, review, taniguchi,

Topics {✒️}

krasg12d-induced ikk2/β/nf-κb activation permissions reprints privacy policy nature portfolio journals nature portfolio editing ikkα-e2f1-bmi1 cascade activated epstein–barr virus-mediated transformation author information authors advertising il-6 feed-forward loop cytokine-driven compensatory proliferation k-ras-induced lung tumorigenesis tgf-β-driven program social media lipopolysaccharide-induced nf-κb activation nf-κb-activating complex engaged rmd open 2 tnf-mediated nf-κb signalling nf-κb subunit p65/rela interferon-sensitive response element interleukin-6-induced epithelial-mesenchymal transition chemotherapy-induced alimentary mucositis nf-κb-dependent induction nf-κb-dependent manner tumour necrosis factor-alpha adenoma-linked barrier defects activation-induced cytidine deaminase steroidal anti-inflammatory drugs nf-κb activation induces carcinogen-induced colorectal tumors myd88-dependent il-6 production hgf/c-met axis mdr2 p-glycoprotein gene anti-cancer agent dmapt c-myc sensitizes cells preventing protein binding transcription factor nf-κb classical nf-κb pathway alternative nf-κb pathway japan cancer society lymphotoxin-driven pathway gp130-mediated stat3 activation nf-κb activation occurs nf-κb activation pathway nf-κb activation triggered nf-κb subunit specificity nf-κb response pathways dissecting molecular cross-talk il-22/il-22r1 axis

Questions {❓}

  • Angiogenesis and chronic inflammation: cause or consequence?
  • Inflammation and cancer: back to Virchow?
  • NF-κB signaling in cancer stem cells: a promising therapeutic target?
  • NSAIDs inhibit tumorigenesis, but how?
  • Notch and NFκB signaling pathways: Do they collaborate in normal vertebrate brain development and function?
  • Redox activation of Nrf2 and NF-κB: a double end sword?
  • Targeting the alternative NF-κB pathway in pancreatic cancer: a new direction for therapy?
  • Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation?

Schema {🗺️}

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