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Title[redir]:
Targeting the alternative NF-κB pathway in pancreatic cancer: a new direction for therapy? - PMC
Description:
Pancreatic cancer, due to its late diagnosis, is difficult to treat. In addition, current therapy options are insufficient and new approaches for combination treatment are required. Recent demonstration of the importance of constitutive signaling of ...
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Keywords {🔍}
nik, doi, cancer, nfκb, pancreatic, pathway, kinase, traf, alternative, inhibitors, pubmed, google, scholar, pmc, target, cells, cell, signaling, article, activation, expression, canonical, free, targeting, activity, ikkα, degradation, levels, proliferation, strategy, nlm, pathways, increased, multiple, shown, inhibit, therapy, approaches, combination, apoptosis, inhibitor, active, domain, pdac, myeloma, specific, inhibition, ncbi, search, rev,
Topics {✒️}
nf-κ b-inducing kinase traf2-nik-nf-κb2 signaling pathway nf-κb-inducing kinase regulates p52/relb nf-κb heterodimer inhibiting nf-κb-inducing kinase nf-κb-inducing kinase �nf-κb-inducing kinase nf-κb inducing kinase noncanonical nf-κb pathway nuclear factor-κb inhibitor alternative nf-κb pathway lymphotoxin-β receptor ltβ nik/nf-κb2 pathway nf-κb2 p100 pmc beta search prevent stimulus-dependent degradation canonical nf-κb pathway suppresses nf-κb activation alternative nf-κb pathways disrupt hsp90/cdc37 complex ikkα controls p52/relb inhibit nf-κb due nf-κb signaling nf-κb subunits enhance bortezomib-induced apoptosis inhibit nf-κb nf-κb pathways pancreatic ductal adenocarcinoma flexible active site κb kinase complex �nf-κb’ inhibitors inhibits nf-κb license information pmcid page abstract introduction mol cancer ther year view regulates antiapoptotic signaling kinase domain reveals pancreatic intraepithelial neoplasia human prostate cancer cancer biol ther basally active kinase active kinase complex cell permeable peptides broad spectrum inhibitor iκb kinase α serine/threonine kinase dominant-active mutant constitutively active conformation publisher site pdf
Questions {❓}
- Is NF-κB a good target for cancer therapy?
- Targeting the alternative NF-κB pathway in pancreatic cancer: a new direction for therapy?
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