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Title:
Targeting minimal residual disease: a path to cure? | Nature Reviews Cancer
Description:
Improved therapies have allowed many patients with cancer to achieve complete remission, but they retain minimal residual disease (MRD), which causes relapse. This Opinion article argues that iterative detection, profiling and targeting of MRD could improve outcomes, including cure rates. Therapeutics that block kinases, transcriptional modifiers, immune checkpoints and other biological vulnerabilities are transforming cancer treatment. As a result, many patients achieve dramatic responses, including complete radiographical or pathological remission, yet retain minimal residual disease (MRD), which results in relapse. New functional approaches can characterize clonal heterogeneity and predict therapeutic sensitivity of MRD at a single-cell level. Preliminary evidence suggests that iterative detection, profiling and targeting of MRD would meaningfully improve outcomes and may even lead to cure.
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nature portfolio journals permissions reprints nature portfolio privacy policy index tonsillar carcinomas interrogating open issues author information authors advertising single-cell rna-seq supports integrative cancer research national library scientific adviser receives research funding social media open-label dana-farber cancer institute nature+ nature 435 nature 539 nature 518 nature single-cell rna-seq guide therapy decision-making research hospital intraductal papillary-mucinous tumors live-cell mass profiling single-cell transcriptomics applied empowering single-cell 'omics' low-cost rna sequencing small-cell lung cancer gov/ct2/show/nct02478125 muscle-invasive bladder cancer single-cell mass accumulation stop 2g-tki study xenografts enables discovery single-cell growth rates circulating-free tumor dna early breast cancer moving treatment-free remission real-time deformability cytometry permissions egfr-mutant nsclc patients springerlink instant access fixable bh3 profiling gastrointestinal stromal tumors predicting patient responses flow cytometric monitoring chronic myeloid leukaemia metastatic breast cancer phase iii randomized
Questions {β}
- Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?
- Has MRD monitoring superseded other prognostic factors in adult ALL?
- MRD in AML: does it already guide therapy decision-making?
- Targeting minimal residual disease: a path to cure?
- Targeting minimal residual disease: a path to cure?
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description:Improved therapies have allowed many patients with cancer to achieve complete remission, but they retain minimal residual disease (MRD), which causes relapse. This Opinion article argues that iterative detection, profiling and targeting of MRD could improve outcomes, including cure rates. Therapeutics that block kinases, transcriptional modifiers, immune checkpoints and other biological vulnerabilities are transforming cancer treatment. As a result, many patients achieve dramatic responses, including complete radiographical or pathological remission, yet retain minimal residual disease (MRD), which results in relapse. New functional approaches can characterize clonal heterogeneity and predict therapeutic sensitivity of MRD at a single-cell level. Preliminary evidence suggests that iterative detection, profiling and targeting of MRD would meaningfully improve outcomes and may even lead to cure.
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