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Title:
Minimum lesion detectability as a measure of PET system performance | EJNMMI Physics
Description:
A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 mm were imaged in a Jaszczak ECT Phantom, in air, in a cold background, and with sphere to background contrast ratios of 15:1 down to 1.88:1. The imaging times varied from 1 to 16 min. The imaging protocol was performed on the Gemini TF and Vereos by Philips, the mCT and HRRT by Siemens, and the Discovery 710 by General Electric. For each scanning condition, the images were reconstructed with image voxel sizes of 1 to 4 mm cubic voxels. The reconstruction method used for each system was the one recommended by the manufacture to achieve best small image lesion detection results. A human observer study was performed to determine the smallest observable sphere for each scanning condition. All systems were able to image the smallest sphere of 3.95 mm inner diameter at the 15 to 1 signal to background ratio when imaged for 16 min. For a typical whole body per bed position scan time of 2 to 4 min, the smallest imaged sphere varied between 4.95 and 6.23 mm at the 15:1 contrast ratio and 12.43 and 15.43 mm at a contrast ratio of 1.88:1. In general, all systems were consistent with the Rose criteria when determining lesion detectability. Besides demonstrating that the current state of the art clinical PET/CT systems have the same lesion detection ability, the study demonstrates how sensitive scan time can be to detecting small lesions which have a relatively small contrast uptake in the range of just 2:1. This should help guide imaging protocols to use longer scan times over regions of the subject in which small lesions are suspect.
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Keywords {🔍}
image, lesion, background, images, study, system, sphere, spheres, pet, voxel, data, contrast, phantom, size, imaging, systems, detection, table, scan, article, ratio, observer, human, signal, min, reconstruction, google, scholar, observed, smallest, lesions, activity, small, time, snr, med, measure, nucl, volume, full, scanning, petct, row, set, measured, research, detectability, performance, results, clinical,
Topics {✒️}
shielah conant & roberto maass-moreno si-photomultiplier-based pet systems positron emission tomography si-photomultiplier-based clinical pet/ct imaging related subjects ect/mi-hs/set4 pet/ct systems undertaken clinical pet/ct systems pet/ct system design body pet/ct systems flight pet/ct scanner nema nu2 test body 18f-fdg pet article download pdf nema nu2 measurements radionuclide-labeled agent full access lesion imaging test pet/ct system stephen adler radionuclide activity measurement lesion scoring scheme privacy choices/manage cookies pet imaging highlights pet/ct systems digital pet prototype guide imaging protocols leidos biomedical research accompanying table 5 list pet imaging data pet tumor imaging minimum lesion size nuclear medicine physicians nuclear medicine technologist philips medical systems minimum lesion detectability pet imaging assessment ect/hs/set6 article adler image voxel size pet scanner performance katherine binzel jun zhang pet lesion detection imaging parameter space medical imaging resulting pet image imaging times varied pet tumor detection
Questions {❓}
- For a lesion of a given size, a tracer uptake to background of a given contrast reconstructed to a given image voxel size, will the lesion be positively observed?
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mainEntity:
headline:Minimum lesion detectability as a measure of PET system performance
description:A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 mm were imaged in a Jaszczak ECT Phantom, in air, in a cold background, and with sphere to background contrast ratios of 15:1 down to 1.88:1. The imaging times varied from 1 to 16 min. The imaging protocol was performed on the Gemini TF and Vereos by Philips, the mCT and HRRT by Siemens, and the Discovery 710 by General Electric. For each scanning condition, the images were reconstructed with image voxel sizes of 1 to 4 mm cubic voxels. The reconstruction method used for each system was the one recommended by the manufacture to achieve best small image lesion detection results. A human observer study was performed to determine the smallest observable sphere for each scanning condition. All systems were able to image the smallest sphere of 3.95 mm inner diameter at the 15 to 1 signal to background ratio when imaged for 16 min. For a typical whole body per bed position scan time of 2 to 4 min, the smallest imaged sphere varied between 4.95 and 6.23 mm at the 15:1 contrast ratio and 12.43 and 15.43 mm at a contrast ratio of 1.88:1. In general, all systems were consistent with the Rose criteria when determining lesion detectability. Besides demonstrating that the current state of the art clinical PET/CT systems have the same lesion detection ability, the study demonstrates how sensitive scan time can be to detecting small lesions which have a relatively small contrast uptake in the range of just 2:1. This should help guide imaging protocols to use longer scan times over regions of the subject in which small lesions are suspect.
datePublished:2017-03-04T00:00:00Z
dateModified:2017-03-04T00:00:00Z
pageStart:1
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license:http://creativecommons.org/licenses/by/4.0/
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keywords:
PET/CT imaging
Lesion detection
Human observer study
Signal to noise
Nuclear Medicine
Imaging / Radiology
Applied and Technical Physics
Computational Mathematics and Numerical Analysis
Engineering
general
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headline:Minimum lesion detectability as a measure of PET system performance
description:A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 mm were imaged in a Jaszczak ECT Phantom, in air, in a cold background, and with sphere to background contrast ratios of 15:1 down to 1.88:1. The imaging times varied from 1 to 16 min. The imaging protocol was performed on the Gemini TF and Vereos by Philips, the mCT and HRRT by Siemens, and the Discovery 710 by General Electric. For each scanning condition, the images were reconstructed with image voxel sizes of 1 to 4 mm cubic voxels. The reconstruction method used for each system was the one recommended by the manufacture to achieve best small image lesion detection results. A human observer study was performed to determine the smallest observable sphere for each scanning condition. All systems were able to image the smallest sphere of 3.95 mm inner diameter at the 15 to 1 signal to background ratio when imaged for 16 min. For a typical whole body per bed position scan time of 2 to 4 min, the smallest imaged sphere varied between 4.95 and 6.23 mm at the 15:1 contrast ratio and 12.43 and 15.43 mm at a contrast ratio of 1.88:1. In general, all systems were consistent with the Rose criteria when determining lesion detectability. Besides demonstrating that the current state of the art clinical PET/CT systems have the same lesion detection ability, the study demonstrates how sensitive scan time can be to detecting small lesions which have a relatively small contrast uptake in the range of just 2:1. This should help guide imaging protocols to use longer scan times over regions of the subject in which small lesions are suspect.
datePublished:2017-03-04T00:00:00Z
dateModified:2017-03-04T00:00:00Z
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Lesion detection
Human observer study
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Applied and Technical Physics
Computational Mathematics and Numerical Analysis
Engineering
general
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