Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nn.4202.

Title:
Melanocortin-4 receptor–regulated energy homeostasis | Nature Neuroscience
Description:
Central melanocortinergic signaling via the melanocortin-4 receptor is both a culprit in and a target for obesity. The authors review our understanding of this evolutionarily conserved system in the regulation of mammalian energy homeostasis. The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components—two antagonistically acting ligands and two cognate receptors—this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Over the last decade the application of conditional genetic techniques has facilitated the neuroanatomical dissection of the melanocortinergic network and identified the specific neural substrates and circuits that underscore the regulation of feeding behavior, energy expenditure, glucose homeostasis and autonomic outflow. In this regard, the melanocortin-4 receptor is a critical coordinator of mammalian energy homeostasis and body weight. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$531,700 per month
Our analysis indicates Nature.com generates between $354,480 and $974,820 monthly online from display ads.

Keywords {🔍}

pubmed, google, scholar, cas, central, melanocortin, receptor, neurons, obesity, nature, nat, receptors, neurosci, mice, cell, feeding, energy, hypothalamic, system, protein, metab, nucleus, physiol, endocrinology, article, endocrinol, agoutirelated, metabolic, agrp, homeostasis, regulation, behavior, access, clin, mcr, brain, diabetes, garfield, control, neural, weight, activation, pomc, res, function, content, krashes, hypothalamus, proopiomelanocortin, mol,

Topics {✒️}

nature portfolio intramural research program permissions reprints privacy policy author information authors advertising agouti-related peptide-expressing neurons social media mc4r-deficient c57bl/6j mice agouti-related protein binding melanocortin-4 receptor-mediated inhibition nature 488 nature 411 nature 487 nature 503 nature 521 nature 520 nature mice lacking pro-opiomelanocortin agouti-related protein functions channelrhodopsin-2-assisted circuit mapping mitogen-activated protein kinase long-range callosal projections negative-valence teaching signal pro-opiomelanocortin deficiency responds melanocortin-4 receptor-regulated appetite g-protein-independent coupling divergent signal-transduction pathways γ2-melanocyte-stimulating hormones flip-flop memory circuit cholecystokinin-mediated suppression personal data central nervous system melanocortin-4 receptor-deficient mice mc4r-expressing glutamatergic neurons central melanocortin system pertussis toxin-sensitive signaling agouti-related protein severe early-onset obesity central melanocortin receptors alpha-melanocyte-stimulating hormone springerlink instant access data protection permissions central melanocortin pathways central melanocortin circuitry agouti-related peptide central receptors mediating taste aversion central melanocortinergic pathways

Questions {❓}

  • “Are melanocortin receptors constitutively active in vivo?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Melanocortin-4 receptor–regulated energy homeostasis
         description:Central melanocortinergic signaling via the melanocortin-4 receptor is both a culprit in and a target for obesity. The authors review our understanding of this evolutionarily conserved system in the regulation of mammalian energy homeostasis. The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components—two antagonistically acting ligands and two cognate receptors—this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Over the last decade the application of conditional genetic techniques has facilitated the neuroanatomical dissection of the melanocortinergic network and identified the specific neural substrates and circuits that underscore the regulation of feeding behavior, energy expenditure, glucose homeostasis and autonomic outflow. In this regard, the melanocortin-4 receptor is a critical coordinator of mammalian energy homeostasis and body weight. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis.
         datePublished:2016-01-27T00:00:00Z
         dateModified:2016-01-27T00:00:00Z
         pageStart:206
         pageEnd:219
         sameAs:https://doi.org/10.1038/nn.4202
         keywords:
            Cell signalling
            Homeostasis
            Neural circuits
            Biomedicine
            general
            Neurosciences
            Behavioral Sciences
            Biological Techniques
            Neurobiology
            Animal Genetics and Genomics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.4202/MediaObjects/41593_2016_Article_BFnn4202_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.4202/MediaObjects/41593_2016_Article_BFnn4202_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.4202/MediaObjects/41593_2016_Article_BFnn4202_Fig3_HTML.jpg
         isPartOf:
            name:Nature Neuroscience
            issn:
               1546-1726
               1097-6256
            volumeNumber:19
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Michael J Krashes
               affiliation:
                     name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
                     address:
                        name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
                     name:National Institute on Drug Abuse, National Institutes of Health
                     address:
                        name:National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Bradford B Lowell
               affiliation:
                     name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alastair S Garfield
               affiliation:
                     name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Centre for Integrative Physiology, University of Edinburgh
                     address:
                        name:Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Melanocortin-4 receptor–regulated energy homeostasis
      description:Central melanocortinergic signaling via the melanocortin-4 receptor is both a culprit in and a target for obesity. The authors review our understanding of this evolutionarily conserved system in the regulation of mammalian energy homeostasis. The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components—two antagonistically acting ligands and two cognate receptors—this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Over the last decade the application of conditional genetic techniques has facilitated the neuroanatomical dissection of the melanocortinergic network and identified the specific neural substrates and circuits that underscore the regulation of feeding behavior, energy expenditure, glucose homeostasis and autonomic outflow. In this regard, the melanocortin-4 receptor is a critical coordinator of mammalian energy homeostasis and body weight. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis.
      datePublished:2016-01-27T00:00:00Z
      dateModified:2016-01-27T00:00:00Z
      pageStart:206
      pageEnd:219
      sameAs:https://doi.org/10.1038/nn.4202
      keywords:
         Cell signalling
         Homeostasis
         Neural circuits
         Biomedicine
         general
         Neurosciences
         Behavioral Sciences
         Biological Techniques
         Neurobiology
         Animal Genetics and Genomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.4202/MediaObjects/41593_2016_Article_BFnn4202_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.4202/MediaObjects/41593_2016_Article_BFnn4202_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.4202/MediaObjects/41593_2016_Article_BFnn4202_Fig3_HTML.jpg
      isPartOf:
         name:Nature Neuroscience
         issn:
            1546-1726
            1097-6256
         volumeNumber:19
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michael J Krashes
            affiliation:
                  name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
                  address:
                     name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
                  name:National Institute on Drug Abuse, National Institutes of Health
                  address:
                     name:National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Bradford B Lowell
            affiliation:
                  name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alastair S Garfield
            affiliation:
                  name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Centre for Integrative Physiology, University of Edinburgh
                  address:
                     name:Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Neuroscience
      issn:
         1546-1726
         1097-6256
      volumeNumber:19
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
      address:
         name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:National Institute on Drug Abuse, National Institutes of Health
      address:
         name:National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA
         type:PostalAddress
      name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Centre for Integrative Physiology, University of Edinburgh
      address:
         name:Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Michael J Krashes
      affiliation:
            name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
            address:
               name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
            name:National Institute on Drug Abuse, National Institutes of Health
            address:
               name:National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Bradford B Lowell
      affiliation:
            name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Alastair S Garfield
      affiliation:
            name:Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Centre for Integrative Physiology, University of Edinburgh
            address:
               name:Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA
      name:National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA
      name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

External Links {🔗}(355)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

4.52s.