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Title[redir]:
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency - PMC
Description:
Over 20 severely obese subjects in 11 independent kindreds have been reported to have pathogenic heterozygous mutations in the gene encoding the melanocortin 4 receptor (MC4R), making this the most common known monogenic cause of human obesity. To ...
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Keywords {π}
subjects, obesity, mutations, doi, mcr, children, affected, age, pubmed, google, scholar, human, bone, body, reported, obese, heterozygous, severe, receptor, found, mutation, energy, wildtype, studies, height, previously, blood, clinical, homozygous, mutant, weight, study, measured, family, melanocortin, gene, earlyonset, cells, sequence, nonobese, data, adults, predicted, deficiency, missense, families, frameshift, normal, increased, composition,
Topics {βοΈ}
camp-responsive reporter plasmid portable free-standing stadiometer single-strand conformational polymorphism vectors expressing wild-type vector expressing wild-type human early-onset obesity persistent food-seeking behavior severe early-onset obesity pro-opiomelanocortin deficiency responds pmc beta search diet-induced weight loss pmc copyright notice protein-coupled signal transduction high blood pressure mc4r-mutant subjects exceeded reported food-seeking behavior mc4r-deficient human subjects endogenous ecori site gender-related reference values working group report caucasian mc4r-deficient subjects advanced epiphyseal maturation publisher site pdf homozygous wild-type children mc4r-deficient children compared dominantly inherited disorder early-onset obesity empty pcdna3 vector single photon absorptiometry bone mineral density conservative amino acid gender-specific normative data dominantly inherited obesity measuring luciferase activity basal metabolic rate diastolic blood pressures central nervous system systolic blood pressure blood pressure nomograms body skeletal mass age-adjusted population range 24-hour urine collection 28-base pairs downstream food-seeking behavior amino acid sequence recombinant leptin therapy license information pmcid resulting luminescence detected mammalian energy homeostasis melanocortin-4 receptor results
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