
NCBI . NLM . NIH . GOV {
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Title[redir]:
Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency - PMC
Description:
Data from mice lacking all endogenous melanocortin peptides suggest Agouti-related-peptide acts in vivo as a melanocortin antagonist rather than an inverse agonist.
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Keywords {🔍}
mice, agrp, pomc, dko, intake, doi, food, pubmed, google, scholar, melanocortin, body, weight, fig, data, administration, mass, central, ndpαmsh, wildtype, pmc, agonist, corticosterone, increase, activity, phenotype, energy, effect, inverse, mcr, lean, control, agoutirelated, receptors, expression, article, mouse, cort, peptide, receptor, studies, pomcagrp, free, model, effects, saline, vivo, peptides, fat, hypothalamic,
Topics {✒️}
dual-energy x-ray absorptiometry d-phe7]-α-msh npy neuropeptide agouti-related peptide-expressing neurons age-matched wild-type controls medical research council-centre neuron-specific proopiomelanocortin-deficient mice orexigenic agouti related-peptide d-phe7]-α-msh generate agouti-related protein pro-opiomelanocortin-derived peptides alpha-melanocyte stimulating hormone α-melanocyte-stimulating hormone gpcr drug discovery brown adipose tissue 2 nmol ndp-α-msh agouti-related protein functions hypothalamo-pituitary thyroid axis agrp [double knockout ndp-α-msh groups mice lacking pro-opiomelanocortin pmc beta search small-intestinal dysfunction accompanies hypothalamic-pituitary-thyroid axis agrp + ndp-α-msh age-related lean phenotype age-matched pomc−/− mice corticosterone-supplemented drinking water γ-aminobutyric acid signaling long-term orexigenic effects endogenous agrp-derived ligands double knockout agouti-related protein late-onset phenotype observed agouti-related peptide severe early-onset obesity agrp-modulating receptor activity wild-type mice caused ndp-α-msh related metabolic disease bat uncoupling protein-1 adenylate cyclase activity putative melanocortin-independent effects significant melanocortin-independent actions decreased ambulatory movement pomc−/−/tg/+ transgenic model enzyme immunoassay kit corticosterone-supplemented pomc−/− mice supplemented drinking water supplementary materials included unlike α-msh
Questions {❓}
- AgRP in energy balance: will the real AgRP please stand up?
- Could AgRP also have a role outside of the melanocortin system?
- So where does this leave our current understanding of AgRP?
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