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         headline:The genetic landscape of high-risk neuroblastoma
         description:John Maris, Matthew Meyerson, Marco Marra and colleagues report results of a large-scale sequencing study of neuroblastoma. They observe a low median exonic mutation frequency and strikingly few recurrently mutated genes in these tumors, highlighting challenges for developing targeted therapeutic strategies based on frequently mutated oncogenic drivers. Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we studied 240 affected individuals (cases) using a combination of whole-exome, genome and transcriptome sequencing as part of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative. Here we report a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in these tumors. Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN11 (2.9%), ATRX (2.5%, and an additional 7.1% had focal deletions), MYCN (1.7%, causing a recurrent p.Pro44Leu alteration) and NRAS (0.83%). Rare, potentially pathogenic germline variants were significantly enriched in ALK, CHEK2, PINK1 and BARD1. The relative paucity of recurrent somatic mutations in neuroblastoma challenges current therapeutic strategies that rely on frequently altered oncogenic drivers.
         datePublished:2013-01-20T00:00:00Z
         dateModified:2013-01-20T00:00:00Z
         pageStart:279
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         sameAs:https://doi.org/10.1038/ng.2529
         keywords:
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            CNS cancer
            Mutation
            Biomedicine
            general
            Human Genetics
            Cancer Research
            Agriculture
            Gene Function
            Animal Genetics and Genomics
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                     name:The Children's Hospital of Philadelphia
                     address:
                        name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                     address:
                        name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
                     name:Perelman School of Medicine at the University of Pennsylvania
                     address:
                        name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Steven J M Jones
               affiliation:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                     address:
                        name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eric S Lander
               affiliation:
                     name:The Broad Institute of MIT and Harvard
                     address:
                        name:The Broad Institute of MIT and Harvard, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stacey B Gabriel
               affiliation:
                     name:The Broad Institute of MIT and Harvard
                     address:
                        name:The Broad Institute of MIT and Harvard, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gad Getz
               affiliation:
                     name:The Broad Institute of MIT and Harvard
                     address:
                        name:The Broad Institute of MIT and Harvard, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert C Seeger
               affiliation:
                     name:The Children's Hospital Los Angeles
                     address:
                        name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
                        type:PostalAddress
                     type:Organization
                     name:Saban Research Institute, The Children's Hospital Los Angeles
                     address:
                        name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
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                     type:Organization
                     name:Keck School of Medicine, University of Southern California
                     address:
                        name:Keck School of Medicine, University of Southern California, Los Angeles, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Javed Khan
               affiliation:
                     name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health
                     address:
                        name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marco A Marra
               affiliation:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                     address:
                        name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                        type:PostalAddress
                     type:Organization
                     name:University of British Columbia
                     address:
                        name:Department of Medical Genetics, University of British Columbia, Vancouver, Canada
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Matthew Meyerson
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                     address:
                        name:The Broad Institute of MIT and Harvard, Cambridge, USA
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                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Dana-Farber Cancer Institute
                     address:
                        name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:John M Maris
               affiliation:
                     name:The Children's Hospital of Philadelphia
                     address:
                        name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                     address:
                        name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
                     name:Perelman School of Medicine at the University of Pennsylvania
                     address:
                        name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
                     name:Abramson Family Cancer Research Institute
                     address:
                        name:Abramson Family Cancer Research Institute, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
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ScholarlyArticle:
      headline:The genetic landscape of high-risk neuroblastoma
      description:John Maris, Matthew Meyerson, Marco Marra and colleagues report results of a large-scale sequencing study of neuroblastoma. They observe a low median exonic mutation frequency and strikingly few recurrently mutated genes in these tumors, highlighting challenges for developing targeted therapeutic strategies based on frequently mutated oncogenic drivers. Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we studied 240 affected individuals (cases) using a combination of whole-exome, genome and transcriptome sequencing as part of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative. Here we report a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in these tumors. Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN11 (2.9%), ATRX (2.5%, and an additional 7.1% had focal deletions), MYCN (1.7%, causing a recurrent p.Pro44Leu alteration) and NRAS (0.83%). Rare, potentially pathogenic germline variants were significantly enriched in ALK, CHEK2, PINK1 and BARD1. The relative paucity of recurrent somatic mutations in neuroblastoma challenges current therapeutic strategies that rely on frequently altered oncogenic drivers.
      datePublished:2013-01-20T00:00:00Z
      dateModified:2013-01-20T00:00:00Z
      pageStart:279
      pageEnd:284
      sameAs:https://doi.org/10.1038/ng.2529
      keywords:
         Cancer genetics
         CNS cancer
         Mutation
         Biomedicine
         general
         Human Genetics
         Cancer Research
         Agriculture
         Gene Function
         Animal Genetics and Genomics
      image:
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.2529/MediaObjects/41588_2013_Article_BFng2529_Fig2_HTML.jpg
      isPartOf:
         name:Nature Genetics
         issn:
            1546-1718
            1061-4036
         volumeNumber:45
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Trevor J Pugh
            affiliation:
                  name:The Broad Institute of MIT and Harvard
                  address:
                     name:The Broad Institute of MIT and Harvard, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Dana-Farber Cancer Institute
                  address:
                     name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Olena Morozova
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                  address:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
                  type:Organization
                  name:University of British Columbia
                  address:
                     name:Department of Medical Genetics, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Edward F Attiyeh
            affiliation:
                  name:The Children's Hospital of Philadelphia
                  address:
                     name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                  address:
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
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                  type:Organization
                  name:Perelman School of Medicine at the University of Pennsylvania
                  address:
                     name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
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            type:Person
            name:Shahab Asgharzadeh
            affiliation:
                  name:The Children's Hospital Los Angeles
                  address:
                     name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
                  name:Saban Research Institute, The Children's Hospital Los Angeles
                  address:
                     name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
                  name:Keck School of Medicine, University of Southern California
                  address:
                     name:Keck School of Medicine, University of Southern California, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jun S Wei
            affiliation:
                  name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health
                  address:
                     name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
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                  type:Organization
            type:Person
            name:Daniel Auclair
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                  name:The Broad Institute of MIT and Harvard
                  address:
                     name:The Broad Institute of MIT and Harvard, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Scott L Carter
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                  name:The Broad Institute of MIT and Harvard
                  address:
                     name:The Broad Institute of MIT and Harvard, Cambridge, USA
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            type:Person
            name:Kristian Cibulskis
            affiliation:
                  name:The Broad Institute of MIT and Harvard
                  address:
                     name:The Broad Institute of MIT and Harvard, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Megan Hanna
            affiliation:
                  name:The Broad Institute of MIT and Harvard
                  address:
                     name:The Broad Institute of MIT and Harvard, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Dana-Farber Cancer Institute
                  address:
                     name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
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            type:Person
            name:Adam Kiezun
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                     name:The Broad Institute of MIT and Harvard, Cambridge, USA
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            name:Jaegil Kim
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            name:Michael S Lawrence
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            name:Lee Lichenstein
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            name:Aaron McKenna
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            name:Chandra Sekhar Pedamallu
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                     name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
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            name:Alex H Ramos
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            name:Erica Shefler
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            name:Chip Stewart
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                  address:
                     name:The Broad Institute of MIT and Harvard, Cambridge, USA
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            name:Adrian Ally
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
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            name:Inanc Birol
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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            name:Martin Hirst
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
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            name:Shaun D Jackman
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
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            name:Baljit Kamoh
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                  address:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alireza Hadj Khodabakshi
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                  address:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
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            type:Person
            name:Martin Krzywinski
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                  address:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
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            type:Person
            name:Allan Lo
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
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            type:Person
            name:Richard A Moore
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                  address:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
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            type:Person
            name:Karen L Mungall
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                  address:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
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            name:Jenny Qian
            affiliation:
                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
                  address:
                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
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            name:Angela Tam
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
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            name:Nina Thiessen
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
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            type:Person
            name:Yongjun Zhao
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                  name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
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                     name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
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            type:Person
            name:Kristina A Cole
            affiliation:
                  name:The Children's Hospital of Philadelphia
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                     name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                  address:
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Perelman School of Medicine at the University of Pennsylvania
                  address:
                     name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
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                  type:Organization
            type:Person
            name:Maura Diamond
            affiliation:
                  name:The Children's Hospital of Philadelphia
                  address:
                     name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                  address:
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Perelman School of Medicine at the University of Pennsylvania
                  address:
                     name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
                     type:PostalAddress
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            type:Person
            name:Sharon J Diskin
            affiliation:
                  name:The Children's Hospital of Philadelphia
                  address:
                     name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                  address:
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Perelman School of Medicine at the University of Pennsylvania
                  address:
                     name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yael P Mosse
            affiliation:
                  name:The Children's Hospital of Philadelphia
                  address:
                     name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                  address:
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Perelman School of Medicine at the University of Pennsylvania
                  address:
                     name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrew C Wood
            affiliation:
                  name:The Children's Hospital of Philadelphia
                  address:
                     name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
                  address:
                     name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Perelman School of Medicine at the University of Pennsylvania
                  address:
                     name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lingyun Ji
            affiliation:
                  name:The Children's Hospital Los Angeles
                  address:
                     name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
                  name:Saban Research Institute, The Children's Hospital Los Angeles
                  address:
                     name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
                  name:Keck School of Medicine, University of Southern California
                  address:
                     name:Keck School of Medicine, University of Southern California, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Richard Sposto
            affiliation:
                  name:The Children's Hospital Los Angeles
                  address:
                     name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
                  name:Saban Research Institute, The Children's Hospital Los Angeles
                  address:
                     name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
                  name:Keck School of Medicine, University of Southern California
                  address:
                     name:Keck School of Medicine, University of Southern California, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Badgett
            affiliation:
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            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
            name:University of British Columbia
            address:
               name:Department of Medical Genetics, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Edward F Attiyeh
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Shahab Asgharzadeh
      affiliation:
            name:The Children's Hospital Los Angeles
            address:
               name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Saban Research Institute, The Children's Hospital Los Angeles
            address:
               name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Keck School of Medicine, University of Southern California
            address:
               name:Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Jun S Wei
      affiliation:
            name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health
            address:
               name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
               type:PostalAddress
            type:Organization
      name:Daniel Auclair
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Scott L Carter
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Kristian Cibulskis
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Megan Hanna
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute
            address:
               name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
               type:PostalAddress
            type:Organization
      name:Adam Kiezun
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Jaegil Kim
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Michael S Lawrence
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Lee Lichenstein
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Aaron McKenna
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Chandra Sekhar Pedamallu
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute
            address:
               name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
               type:PostalAddress
            type:Organization
      name:Alex H Ramos
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Erica Shefler
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Andrey Sivachenko
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Carrie Sougnez
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Chip Stewart
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Adrian Ally
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Inanc Birol
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Readman Chiu
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Richard D Corbett
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Martin Hirst
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Shaun D Jackman
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Baljit Kamoh
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Alireza Hadj Khodabakshi
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Martin Krzywinski
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Allan Lo
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Richard A Moore
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Karen L Mungall
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Jenny Qian
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Angela Tam
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Nina Thiessen
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Yongjun Zhao
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Kristina A Cole
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Maura Diamond
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Sharon J Diskin
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Yael P Mosse
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Andrew C Wood
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Lingyun Ji
      affiliation:
            name:The Children's Hospital Los Angeles
            address:
               name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Saban Research Institute, The Children's Hospital Los Angeles
            address:
               name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Keck School of Medicine, University of Southern California
            address:
               name:Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Richard Sposto
      affiliation:
            name:The Children's Hospital Los Angeles
            address:
               name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Saban Research Institute, The Children's Hospital Los Angeles
            address:
               name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Keck School of Medicine, University of Southern California
            address:
               name:Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Thomas Badgett
      affiliation:
            name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health
            address:
               name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
               type:PostalAddress
            type:Organization
      name:Wendy B London
      affiliation:
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Children's Hospital Boston/Dana-Farber Cancer Institute and Children's Oncology Group
            address:
               name:Children's Hospital Boston/Dana-Farber Cancer Institute and Children's Oncology Group, Boston, USA
               type:PostalAddress
            type:Organization
      name:Yvonne Moyer
      affiliation:
            name:Biopathology Center, Nationwide Children's Hospital
            address:
               name:Biopathology Center, Nationwide Children's Hospital, Columbus, USA
               type:PostalAddress
            type:Organization
            name:The Ohio State University College of Medicine
            address:
               name:The Ohio State University College of Medicine, Columbus, USA
               type:PostalAddress
            type:Organization
      name:Julie M Gastier-Foster
      affiliation:
            name:Biopathology Center, Nationwide Children's Hospital
            address:
               name:Biopathology Center, Nationwide Children's Hospital, Columbus, USA
               type:PostalAddress
            type:Organization
            name:The Ohio State University College of Medicine
            address:
               name:The Ohio State University College of Medicine, Columbus, USA
               type:PostalAddress
            type:Organization
      name:Malcolm A Smith
      affiliation:
            name:Cancer Therapy Evaluation Program, National Cancer Institute
            address:
               name:Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Jaime M Guidry Auvil
      affiliation:
            name:Office of Cancer Genomics, National Cancer Institute
            address:
               name:Office of Cancer Genomics, National Cancer Institute, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Daniela S Gerhard
      affiliation:
            name:Office of Cancer Genomics, National Cancer Institute
            address:
               name:Office of Cancer Genomics, National Cancer Institute, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Michael D Hogarty
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Steven J M Jones
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Eric S Lander
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Stacey B Gabriel
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Gad Getz
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Robert C Seeger
      affiliation:
            name:The Children's Hospital Los Angeles
            address:
               name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Saban Research Institute, The Children's Hospital Los Angeles
            address:
               name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:Keck School of Medicine, University of Southern California
            address:
               name:Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Javed Khan
      affiliation:
            name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health
            address:
               name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
               type:PostalAddress
            type:Organization
      name:Marco A Marra
      affiliation:
            name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia
            address:
               name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
            name:University of British Columbia
            address:
               name:Department of Medical Genetics, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Matthew Meyerson
      affiliation:
            name:The Broad Institute of MIT and Harvard
            address:
               name:The Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute
            address:
               name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:John M Maris
      affiliation:
            name:The Children's Hospital of Philadelphia
            address:
               name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia
            address:
               name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Perelman School of Medicine at the University of Pennsylvania
            address:
               name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Abramson Family Cancer Research Institute
            address:
               name:Abramson Family Cancer Research Institute, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:Harvard Medical School, Boston, USA
      name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Department of Medical Genetics, University of British Columbia, Vancouver, Canada
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:Harvard Medical School, Boston, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
      name:Harvard Medical School, Boston, USA
      name:Children's Hospital Boston/Dana-Farber Cancer Institute and Children's Oncology Group, Boston, USA
      name:Biopathology Center, Nationwide Children's Hospital, Columbus, USA
      name:The Ohio State University College of Medicine, Columbus, USA
      name:Biopathology Center, Nationwide Children's Hospital, Columbus, USA
      name:The Ohio State University College of Medicine, Columbus, USA
      name:Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, USA
      name:Office of Cancer Genomics, National Cancer Institute, Bethesda, USA
      name:Office of Cancer Genomics, National Cancer Institute, Bethesda, USA
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:Division of Hematology/Oncology, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Saban Research Institute, The Children's Hospital Los Angeles, Los Angeles, USA
      name:Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Pediatric Oncology Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Gaithersburg, USA
      name:Genome Sciences Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada
      name:Department of Medical Genetics, University of British Columbia, Vancouver, Canada
      name:The Broad Institute of MIT and Harvard, Cambridge, USA
      name:Harvard Medical School, Boston, USA
      name:Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
      name:Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, USA
      name:Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
      name:Abramson Family Cancer Research Institute, Philadelphia, USA
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