
NCBI . NLM . NIH . GOV {
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Title[redir]:
MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS - PMC
Description:
Medulloblastomas are the most common malignant brain tumors in children1. Identifying and understanding the genetic events that drive these tumors is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. ...
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Keywords {🔍}
mutations, doi, tumors, ddxx, scholar, google, medulloblastoma, pubmed, genes, pmc, article, mutated, tumor, somatic, rna, helicase, figure, free, sequencing, supplemental, table, analysis, complex, data, domains, group, mutation, mutant, ncor, cell, betacatenin, histone, domain, human, medulloblastomas, subtypes, copy, bcor, wnt, subgroup, significant, mll, shh, protein, samples, loss, found, cancer, nlm, nature,
Topics {✒️}
single-molecule real-time sequencing /projects/genome/assembly/grc/index pathogenic wnt/beta-catenin signaling pathogenic beta-catenin signaling pmc beta search n-cor repression complex12 nonsense/splice site/indel mutations mutant beta-catenin lentivirus wilcoxon rank-sum test bmbf icgc-pedbrain project repressive n-cor complex12 swi/snf nucleosome remodellers lim-binding domains bind sample-specific mutation rate g1 growth-control genes wild type beta-catenin wild-type beta-catenin atp-dependent rna helicase alter ddx3x-rna interaction helicase c-terminal domain helicase atp-binding domain primary tissue specimen green = coiled-coil foundation scholar award functional characterization studies subtype-specific analysis [google scholar] 2 mutant beta-catenin copy number alterations exome hybrid capture specific demethylase 6a copy number profiles enhance beta-catenin human genome sequencing copy number profiles2–5 dexh box motif ddx3x/beta-catenin protein-protein interactions statistically significant frequencies determine histological subtype ortholog vasa/ddx420 genome reference consortium genome-scale sequencing sample barcoding methods integrated genomics identifies mutsig gene names single-stranded rna splice site mutation statistically significant frequency jnk/mapk signaling
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