
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mutations in CHEK2 Associated with Prostate Cancer Risk - PMC
Description:
The DNA-damage–signaling pathway has been implicated in all human cancers. However, the genetic defects and the mechanisms of this pathway in prostate carcinogenesis remain poorly understood. In this study, we analyzed CHEK2, the upstream regulator ...
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Keywords {🔍}
cancer, prostate, mutations, chek, mutation, pubmed, google, scholar, families, doi, familial, patients, men, control, mim, family, group, germline, breast, dna, individuals, identified, brca, gene, ilethr, kinase, pathway, unaffected, cell, chk, groups, analysis, affected, pmc, cancers, study, genes, risk, data, blood, lfs, evidence, delc, present, genet, dnadamagesignaling, genomic, free, table, development,
Topics {✒️}
dna-damage–signaling pathway plays subsequent sex-hormone assays dna-damage–activated protein kinases pmc copyright notice pmc beta search dna double-strand breaks prostate-specific antigen abnormalities dna damage-induced activation phospho-dependent signaling mechanisms population-based control group serum prostate-specific antigen dna-damage–signaling pathway epstein-barr virus cell-cycle checkpoint control ebv-transformed cell lines heritable cancer-prone syndromes prostate cancer-susceptibility locus age-specific reference ranges merck research laboratory prostate-cancer tumor samples multiple low-penetrance genes license information pmcid united states government autosomal dominant model community-based population digital rectal examination highly-penetrant genes normal lymphocyte cells cell lines carrying splice donor site highly penetrant effect dna-damage–signaling dna-damage signaling prostate cancer demonstrated atm-dependent fashion underlying susceptibility locus major susceptibility locus genome-wide search publisher site pdf candidate susceptibility genes dna-damage agents low-penetrance susceptibility inherited cancer predisposition germ-line mutations family history information clinical urologic examination western blot analysis control dna samples defense grant damd17-02-1-0093 replication checkpoint enforced
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