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We are analyzing https://www.nature.com/articles/cmi2017135.

Title:
The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally? | Cellular & Molecular Immunology
Description:
Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the purification of monocyte chemoattractant protein-1 (MCP-1) from culture supernatants of mitogen-activated peripheral blood mononuclear cells and tumor cells. MCP-1 is a potent monocyte-attracting chemokine, identical to the previously described lymphocyte-derived chemotactic factor or tumor-derived chemotactic factor, and greatly contributes to the recruitment of blood monocytes into sites of inflammatory responses and tumors. Because in vitro-cultured tumor cells often produce significant amounts of MCP-1, tumor cells are considered to be the main source of MCP-1. However, various non-tumor cells in the tumor stroma also produce MCP-1 in response to stimuli. Studies performed in vitro and in vivo have provided evidence that MCP-1 production in tumors is a consequence of complex interactions between tumor cells and non-tumor cells and that both tumor cells and non-tumor cells contribute to the production of MCP-1. Although MCP-1 production was once considered to be a part of host defense against tumors, it is now believed to regulate the vicious cycle between tumor cells and macrophages that promotes the progression of tumors.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Education
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Keywords {🔍}

pubmed, google, scholar, cas, article, cancer, cells, monocyte, central, chemoattractant, protein, cell, mcp, tumor, immunol, human, yoshimura, nature, macrophage, macrophages, breast, res, ccl, expression, chemokine, chemotactic, factor, access, gene, content, metastasis, natl, monocytes, tumors, usa, analysis, molecular, host, leonard, mol, biol, receptors, cookies, recruitment, vitro, vivo, production, matsushima, nat, clin,

Topics {✒️}

nature portfolio permissions reprints privacy policy granulocyte/macrophage colony-stimulating factor advertising nf-kb/rel subunit specificity nature 2009 nature 2015 nature 2011 nature 2014 nature chemically defined media platelet-derived growth factor macrophage-csf-dependent macrophage responses lymphocyte-derived chemotactic factor tumor-derived chemotactic factor lymphocyte-derived chemotactic factors development monocyte-derived macrophage subpopulation facilitate breast-tumour metastasis short-lived intermediary reactions cell-free substances formed lymphoid cell-antigen interaction ccl2/ccr2 signalling recruits potent monocyte-attracting chemokine author information authors tumor-promoting activities autocrine tumor-promoting network social media ccl2 mediates cross-talk monocyte chemoattractant protein-1 monocyte-chemoattractant protein-1 malignant pleural effusion personal data vitro-cultured tumor cells transformed cells stimulated springerlink instant access lewis lung carcinoma host defense cytokines data protection permissions macrophage chemoattractant protein-1 destructive cascade mediated author correspondence author declares monocyte chemoattractant proteins monocyte secretory protein inflammatory chemokines ccl2 human breast cancer fibrosarcoma cell growth

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The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?
The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

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