We are analyzing https://link.springer.com/article/10.1186/bcr77.

Title:
Nontransgenic models of breast cancer | Breast Cancer Research
Description:
Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and histopathology of human disease, and allow for basic investigations into underlying cellular and molecular mechanisms. We describe two types of models: those that are directed toward early events in breast cancer development (hyperplastic alveolar nodules [HAN] murine model, MCF10AT human xenograft model); and those that seek to reflect the spectrum of metastatic disease (murine sister cell lines 67, 168, 4T07, 4T1). Collectively, these models provide cell lines that represent all of the sequential stages of progression in breast disease, which can be modified to test the effect of genetic changes.
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Keywords {🔍}

cancer, breast, models, human, cells, google, scholar, mcfat, disease, model, cas, pubmed, lines, mammary, article, development, progression, metastatic, cell, miller, mouse, heppner, tumors, lesions, carcinoma, spectrum, tumor, estrogen, res, research, shekhar, han, xenograft, women, proliferative, preneoplastic, heterogeneous, dcis, spontaneously, tait, genetic, specific, high, histologic, single, privacy, cookies, number, biology, reflect,

Topics {✒️}

t24-ha-ras-transformed derivative gland-free mammary fatpads c-ha-ras oncogene activated c-ha-ras geneticin-resistant subline 67nr mutant ha-ras gene privacy choices/manage cookies proliferative breast disease malathy shekhar breast cancer metastasis cultured cell lines nonmetastatic cell lines mcf10ca1 cell lines human breast cancer human breast tumors mutant ha-ras metastatic cell lines human breast cancers ras gene alterations normal ha-ras [9 estrogen receptor alpha pre-malignant lesions invasive carcinomas generated ras p21 expression developing breast cancer early breast cancer express high levels clin exp metastasis malignant cell sublines human lesions exist transplanted epithelium expands rapidly growing adenocarcinomas 'spontaneous' mammary tumors preinvasive mammary tumors premalignant mcf10at xenografts breast cancer progression estrogen receptor function inbred mouse models histologically normal ducts mouse mammary tumorigenesis natl cancer inst breast cancer development mouse mammary tumors mouse mammary tumor european economic area frequently involving exposure rare mutational event rapid morphological conversion distinctive immunohistochemical staining klein-szanto aj

Schema {🗺️}

WebPage:
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         headline:Nontransgenic models of breast cancer
         description:Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and histopathology of human disease, and allow for basic investigations into underlying cellular and molecular mechanisms. We describe two types of models: those that are directed toward early events in breast cancer development (hyperplastic alveolar nodules [HAN] murine model, MCF10AT human xenograft model); and those that seek to reflect the spectrum of metastatic disease (murine sister cell lines 67, 168, 4T07, 4T1). Collectively, these models provide cell lines that represent all of the sequential stages of progression in breast disease, which can be modified to test the effect of genetic changes.
         datePublished:2000-10-01T00:00:00Z
         dateModified:2000-10-01T00:00:00Z
         pageStart:1
         pageEnd:4
         sameAs:https://doi.org/10.1186/bcr77
         keywords:
            metastasis
            progression
            proliferative breast diseases
            xenografts
            Cancer Research
            Oncology
            Surgical Oncology
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ScholarlyArticle:
      headline:Nontransgenic models of breast cancer
      description:Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and histopathology of human disease, and allow for basic investigations into underlying cellular and molecular mechanisms. We describe two types of models: those that are directed toward early events in breast cancer development (hyperplastic alveolar nodules [HAN] murine model, MCF10AT human xenograft model); and those that seek to reflect the spectrum of metastatic disease (murine sister cell lines 67, 168, 4T07, 4T1). Collectively, these models provide cell lines that represent all of the sequential stages of progression in breast disease, which can be modified to test the effect of genetic changes.
      datePublished:2000-10-01T00:00:00Z
      dateModified:2000-10-01T00:00:00Z
      pageStart:1
      pageEnd:4
      sameAs:https://doi.org/10.1186/bcr77
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         metastasis
         progression
         proliferative breast diseases
         xenografts
         Cancer Research
         Oncology
         Surgical Oncology
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            affiliation:
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                  address:
                     name:Karmanos Cancer Institute, Detroit, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fred R Miller
            affiliation:
                  name:Karmanos Cancer Institute
                  address:
                     name:Karmanos Cancer Institute, Detroit, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:PV Malathy Shekhar
            affiliation:
                  name:Karmanos Cancer Institute
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      name:Karmanos Cancer Institute
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         name:Karmanos Cancer Institute, Detroit, USA
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Person:
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            address:
               name:Karmanos Cancer Institute, Detroit, USA
               type:PostalAddress
            type:Organization
      name:Fred R Miller
      affiliation:
            name:Karmanos Cancer Institute
            address:
               name:Karmanos Cancer Institute, Detroit, USA
               type:PostalAddress
            type:Organization
      name:PV Malathy Shekhar
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            name:Karmanos Cancer Institute
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PostalAddress:
      name:Karmanos Cancer Institute, Detroit, USA
      name:Karmanos Cancer Institute, Detroit, USA
      name:Karmanos Cancer Institute, Detroit, USA

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