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Title:
Antibodies as Cancer Immunotherapy | SpringerLink
Description:
Infused antibodies are the most successful immune-based agents to treat certain cancers. However, their modes of action are not always dependent on immune mechanisms aside from antigen-specific targeting. Immune mechanisms include direct and indirect cytotoxicity...
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google, scholar, pubmed, article, cas, cancer, clin, patients, oncol, phase, antibody, metastatic, growth, antibodies, monoclonal, treatment, receptor, study, factor, human, therapy, res, trial, clinical, med, colorectal, bevacizumab, cell, breast, immunotherapy, advanced, epidermal, iii, survival, tumor, rituximab, immunol, cetuximab, nat, rev, lymphoma, blood, combination, randomized, chapter, targeting, results, biol, therapeutic, engl,
Topics {βοΈ}
yttrium-90-labeled anti-carcinoembryonic antigen 131i-a5b7 anti-cea antibody adult t-cell leukemia-lymphoma diffuse large-b-cell lymphoma cancer-related anorexia/cachexia syndrome anti-plgf inhibits growth epidermal growth factor anti-muc1 antibody as1402 anti-cd52 monoclonal antibody anti-cd20 monoclonal antibody month download article/chapter peripheral t-cell lymphoma folate receptor-targeted therapeutics neu differentiation factor/neuregulin tumour necrosis factor anti-cd20 antibody immunotherapy potent labetuzumab-sn-38 immunoconjugates facilitate breast-tumour metastasis oxidized mannan-muc1 [isrctn71711835] growth factor receptors anti-egfr targeted drugs small-cell lung cancer fc receptor-dependent mechanisms successful immune-based agents egfr-targeted monoclonal antibodies cea-producing advanced malignancies tyrosine kinase inhibition inhibitor-resistant tumors chronic lymphocytic leukemia bloodβbrain barrier disruption antibody targeting trail-r1 fully human antibodies humanized monoclonal antibody refractory multiple myeloma response-independent survival benefit human breast cancer fibroblast activation protein human monoclonal antibodies monoclonal antibody production indolent multiple myeloma anti-cardiolipin idiotype t-cell lymphomas cd30-positive malignancies cancer-related inflammation endothelial cell survival alphavbeta3 integrin receptor current fda-approved antibodies egf receptor family b-cell malignancies metastatic breast cancer
Questions {β}
- Perez-Soler R (2003) Can rash associated with HER1/EGFR inhibition be used as a marker of treatment outcome?
- Silverstein AM (2002) The collected papers of Paul Ehrlich: why was volume 4 never published?
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ScholarlyArticle:
headline:Antibodies as Cancer Immunotherapy
pageEnd:376
pageStart:335
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-4732-0.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Cancer Immunotherapy
isbn:
978-1-4614-4732-0
978-1-4614-4731-3
type:Book
publisher:
name:Springer New York
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type:ImageObject
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author:
name:Devalingam Mahalingam
affiliation:
name:University of Texas Health Science Center, Adult Cancer Program, STRF MC8252
address:
name:Cancer Therapy & Research Center, University of Texas Health Science Center, Adult Cancer Program, STRF MC8252, San Antonio, USA
type:PostalAddress
type:Organization
type:Person
name:Tyler J. Curiel
affiliation:
name:University of Texas Health Science Center, Adult Cancer Program, STRF MC8252
address:
name:Cancer Therapy & Research Center, University of Texas Health Science Center, Adult Cancer Program, STRF MC8252, San Antonio, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Epidermal Growth Factor Receptor, Human Epidermal Growth Factor Receptor, Chronic Lymphocytic Leukemia, Metastatic Colorectal Cancer, KRAS Mutation
description:Infused antibodies are the most successful immune-based agents to treat certain cancers. However, their modes of action are not always dependent on immune mechanisms aside from antigen-specific targeting. Immune mechanisms include direct and indirect cytotoxicity while nonimmune mechanisms include the targeting of toxins, such as drugs or irradiation sources, directly to the tumor, the subject of
Chap. 12
. Therapeutic antibodies can be chimeric or humanized (part human and part animal, usually mouse), but fully human antibodies are in trials or have been FDA approved. This chapter will summarize the current FDA-approved antibodies to treat cancer, and highlight promising antibodies in development.
datePublished:2013
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name:University of Texas Health Science Center, Adult Cancer Program, STRF MC8252
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name:Cancer Therapy & Research Center, University of Texas Health Science Center, Adult Cancer Program, STRF MC8252, San Antonio, USA
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