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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/s13073-017-0450-0.

Title:
Advances in the delivery of RNA therapeutics: from concept to clinical reality | Genome Medicine
Description:
The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes. RNA-based drugs, including short interfering RNAs and antisense oligonucleotides, are particularly promising examples of this newer class of biologics. For over two decades, researchers have been trying to overcome major challenges for utilizing such RNAs in a therapeutic context, including intracellular delivery, stability, and immune response activation. This research is finally beginning to bear fruit as the first RNA drugs gain FDA approval and more advance to the final phases of clinical trials. Furthermore, the recent advent of CRISPR, an RNA-guided gene-editing technology, as well as new strides in the delivery of messenger RNA transcribed in vitro, have triggered a major expansion of the RNA-therapeutics field. In this review, we discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies, and present an overview of the applications of RNA-based drugs for modulation of gene/protein expression and genome editing that are currently being investigated both in the laboratory as well as in the clinic.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,542,081 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

pubmed, article, cas, google, scholar, delivery, rna, mrna, central, gene, editing, nat, protein, clinical, vivo, genome, crisprcas, sirna, cells, expression, therapeutics, nanoparticles, dna, drugs, therapeutic, therapy, biotechnol, trials, nucleic, cancer, proteins, diseases, modified, mice, nature, development, cell, materials, chemical, efficacy, translation, human, modifications, antisense, lipid, liver, systemic, rev, science, rnas,

Topics {✒️}

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Questions {❓}

  • Functional genomics and rheumatoid arthritis: where have we been and where should we go?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Advances in the delivery of RNA therapeutics: from concept to clinical reality
         description:The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes. RNA-based drugs, including short interfering RNAs and antisense oligonucleotides, are particularly promising examples of this newer class of biologics. For over two decades, researchers have been trying to overcome major challenges for utilizing such RNAs in a therapeutic context, including intracellular delivery, stability, and immune response activation. This research is finally beginning to bear fruit as the first RNA drugs gain FDA approval and more advance to the final phases of clinical trials. Furthermore, the recent advent of CRISPR, an RNA-guided gene-editing technology, as well as new strides in the delivery of messenger RNA transcribed in vitro, have triggered a major expansion of the RNA-therapeutics field. In this review, we discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies, and present an overview of the applications of RNA-based drugs for modulation of gene/protein expression and genome editing that are currently being investigated both in the laboratory as well as in the clinic.
         datePublished:2017-06-27T00:00:00Z
         dateModified:2017-06-27T00:00:00Z
         pageStart:1
         pageEnd:16
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13073-017-0450-0
         keywords:
            Antisense oligonucleotide
            Clinical trial
            CRISPR
            Gene editing
            Gene therapy
            Messenger RNA delivery
            mRNA vaccine
            RNA nanoparticle
            Short interfering RNA delivery
            Human Genetics
            Metabolomics
            Bioinformatics
            Medicine/Public Health
            general
            Cancer Research
            Systems Biology
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            name:Genome Medicine
            issn:
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                        type:PostalAddress
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                     name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
                     address:
                        name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
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               affiliation:
                     name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
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                        name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
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                     address:
                        name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
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                     address:
                        name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology
                     address:
                        name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
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ScholarlyArticle:
      headline:Advances in the delivery of RNA therapeutics: from concept to clinical reality
      description:The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes. RNA-based drugs, including short interfering RNAs and antisense oligonucleotides, are particularly promising examples of this newer class of biologics. For over two decades, researchers have been trying to overcome major challenges for utilizing such RNAs in a therapeutic context, including intracellular delivery, stability, and immune response activation. This research is finally beginning to bear fruit as the first RNA drugs gain FDA approval and more advance to the final phases of clinical trials. Furthermore, the recent advent of CRISPR, an RNA-guided gene-editing technology, as well as new strides in the delivery of messenger RNA transcribed in vitro, have triggered a major expansion of the RNA-therapeutics field. In this review, we discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies, and present an overview of the applications of RNA-based drugs for modulation of gene/protein expression and genome editing that are currently being investigated both in the laboratory as well as in the clinic.
      datePublished:2017-06-27T00:00:00Z
      dateModified:2017-06-27T00:00:00Z
      pageStart:1
      pageEnd:16
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13073-017-0450-0
      keywords:
         Antisense oligonucleotide
         Clinical trial
         CRISPR
         Gene editing
         Gene therapy
         Messenger RNA delivery
         mRNA vaccine
         RNA nanoparticle
         Short interfering RNA delivery
         Human Genetics
         Metabolomics
         Bioinformatics
         Medicine/Public Health
         general
         Cancer Research
         Systems Biology
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-017-0450-0/MediaObjects/13073_2017_450_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-017-0450-0/MediaObjects/13073_2017_450_Fig2_HTML.gif
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            1756-994X
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            Periodical
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         name:BioMed Central
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            name:James C. Kaczmarek
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                  name:Department of Chemical Engineering, Massachusetts Institute of Technology
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                     name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
                  address:
                     name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Piotr S. Kowalski
            affiliation:
                  name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
                  address:
                     name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel G. Anderson
            affiliation:
                  name:Department of Chemical Engineering, Massachusetts Institute of Technology
                  address:
                     name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
                  address:
                     name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology
                  address:
                     name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology
                  address:
                     name:Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
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      name:BioMed Central
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Department of Chemical Engineering, Massachusetts Institute of Technology
      address:
         name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
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      address:
         name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
      address:
         name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Department of Chemical Engineering, Massachusetts Institute of Technology
      address:
         name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
      address:
         name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology
      address:
         name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology
      address:
         name:Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
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Person:
      name:James C. Kaczmarek
      affiliation:
            name:Department of Chemical Engineering, Massachusetts Institute of Technology
            address:
               name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
            address:
               name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Piotr S. Kowalski
      affiliation:
            name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
            address:
               name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Daniel G. Anderson
      affiliation:
            name:Department of Chemical Engineering, Massachusetts Institute of Technology
            address:
               name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
            address:
               name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology
            address:
               name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology
            address:
               name:Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
      name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
      name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
      name:Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
      name:David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
      name:Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA
      name:Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, USA

External Links {🔗}(547)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Particles.js
  • Prism.js

CDN Services {📦}

  • Crossref

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