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Title[redir]:
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing - PMC
Description:
Individuals with naturally occurring loss-of-function PCSK9 mutations experience reduced blood low-density lipoprotein cholesterol (LDL-C) levels and protection against cardiovascular disease. The goal of this study was to assess whether genome ...
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Keywords {🔍}
pcsk, mice, levels, virus, cholesterol, crisprcas, doi, plasma, crisprpcsk, liver, gene, mutagenesis, gfp, cas, figure, genome, adenovirus, days, pmc, guide, mutations, disease, performed, site, vivo, editing, mouse, offtarget, chd, groups, control, pubmed, google, scholar, article, lossoffunction, blood, ldlc, exon, surveyor, group, nlm, reduced, cardiovascular, therapeutic, therapy, online, receiving, shows, lipoprotein,
Topics {✒️}
low-density lipoprotein cholesterol enzyme-linked immunosorbent assay acronyms footnotes references homologous end-joining coronary heart disease xml nihms604550-supplement-circres_circres-2014-304351d_xml low ldl cholesterol low-frequency events crispr-cas9 genome-editing system effective pcsk9-genome-editing therapy pcsk9-targeting monoclonal antibodies wild-type mice ldl receptor supplementary materials included virus-free delivery method low ldl transiently expresses crispr-cas9 crispr-cas9 system disrupts crispr-cas9 genome editing candidate guide rnas crispr-pcsk9 mice compared pmc beta search standard liver-targeting adeno crispr-pcsk9 virus showed therapeutic crispr-cas9 applications crispr/cas systems coronary disease nonstandard abbreviations displayed substantial levels synthetic guide rna lowers blood cholesterol short-lived ldlr protein lipoprotein livers receiving crispr-cas9 decreased plasma cholesterol 3t3-l1 cells transfected high-efficiency genome editing assessed ldlr levels observing reduced hdl reduced plasma pcsk9 received crispr-pcsk9 virus plasma cholesterol levels significantly lower levels long-term solution crispr-cas9 system data availability statements 8 crispr-cas9 generates crispr-cas9 activity multiplex genome engineering
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