
NCBI . NLM . NIH . GOV {
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Title[redir]:
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice - PMC
Description:
Here, we study the intricate relationship between gut microbiota and host cometabolic phenotypes associated with dietary-induced impaired glucose homeostasis and nonalcoholic fatty liver disease (NAFLD) in a mouse strain (129S6) known to be ...
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Keywords {🔍}
doi, mice, google, scholar, fig, pubmed, hfd, balbc, plasma, metabolic, choline, glucose, gut, microbiota, liver, nafld, nmr, lfd, methylamines, insulin, metabolism, diet, science, pmc, strain, urine, urinary, pnas, nicholson, dietary, levels, strains, article, tma, profiling, information, symbiotic, data, tolerance, response, compared, free, fatty, excretion, variation, metabolites, significantly, induction, site, sci,
Topics {✒️}
build orthogonal partial glucose tolerance test high-fat diet reduces prolonged high-fat feeding trimethylamine-n-oxide squares-discriminant analysis low-molecular-mass metabolites 10% 2h2o/h2o vol/vol 20% 2h2o/h2o vol/vol 40% high-fat diet metabolic systems-biology approach pmc beta search glucose-stimulated insulin secretion e-stained liver sections strain-matched lfd-fed mice glucose-induced insulin secretion modulate gut-microbial composition free fatty acids metabolic cross-talk fat-fed 129s6 mice prolonged fat-feeding discriminant analysis version gut-microbial metabolism alters fat-feeding induces nafld-sensitive 129s6 mouse exclusively bacterial-origin methylamines low plasma phosphatidylcholine supplementary materials included impaired glucose tolerance high urinary excretion altered gut-microbial metabolism fatty liver phenotype glucose tolerance tests improved glucose tolerance glucose tolerance testing germ-free animals liver fat content squares regression method high-density lipoprotein ir-related processes 1h nmr spectra germ-free rats germ-free mice diet-induced mechanism low-density lipoprotein low-density lipoprotein 1h nmr spectroscopy gut-microbial metabolite variation choline-deficient diet lfd-fed 129s6 mice
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