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Title[redir]:
Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease | Digestive Diseases and Sciences
Description:
The gastrointestinal (GI) microbiome is recognized for potential clinical relevance in inflammatory bowel disease (IBD). Data suggest that there is a disease-dependent loss of microbial diversity in IBD. Trimethylamine-N-oxide (TMAO) is generated by GI anaerobes through the digestion of dietary phosphatidylcholine and carnitine in a microbial-mammalian co-metabolic pathway. IBD-related changes in the gut microbiome may result in disease-specific changes in TMAO plasma concentrations. To determine whether TMAO plasma levels in IBD are altered compared to controls and whether they correlate with disease presence or activity. Liquid chromatography–tandem mass spectrometry was used to measure TMAO, choline, and carnitine plasma levels in 479 subjects (373 non-IBD controls, 106 IBD). Subjects were also genotyped for the flavin monooxygenase (FMO)3 variants, E158K and E308G. Plasma TMAO levels were 2.27 µM lower in the IBD population compared to the control population (p = 0.0001). Lower TMAO levels were similarly seen in active ulcerative colitis (UC) (1.56 µM) versus inactive disease (3.40 µM) (p = 0.002). No difference was seen in active Crohn’s disease (CD) versus inactive CD. No intergroup variation existed in plasma TMAO levels based on FMO3 genotype. Choline levels were higher in IBD, while carnitine levels were similar between the two groups, suggesting that lower TMAO levels in IBD were not due to dietary differences. Decreased TMAO levels are seen in IBD compared to a non-IBD population. These data suggest that TMAO may have potential as a biomarker to support IBD diagnosis as well as to assess disease activity in UC.
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Keywords {🔍}
article, pubmed, google, scholar, cas, bowel, disease, inflammatory, central, gut, microbiome, tmao, ibd, levels, microbiota, intestinal, human, diseases, microbial, trimethylaminenoxide, activity, gastroenterology, dis, nature, research, study, inflamm, department, western, university, london, privacy, cookies, content, analysis, data, wilson, clinical, diversity, plasma, fmo, colitis, crohns, access, med, wang, metabolism, medicine, canada, publish,
Topics {✒️}
article google scholar month download article/chapter trimethylamine-n-oxide production short-chain fatty acid active ulcerative colitis article digestive diseases trimethylamine-n-oxide crohn’s-disease activity full article pdf yun-hee choi inflammatory bowel disease bmc res notes privacy choices/manage cookies inflammatory bowel diseases bennett bj gut microbial–mammalian apical membrane vesicles inflamm bowel dis irritable bowel syndrome versus inactive disease assess disease activity microbial community imbalances patel na medical sciences building article wilson rat distal colon tmao plasma levels disease-dependent loss tmao plasma concentrations culture-independent analysis human gut microbiota european economic area c-reactive protein northern european countries hum mol genet glycyl radical enzyme da costa ka cancer care ontario ethics declarations conflict gut microbiome structure pharmacol exp therap conditions privacy policy population-based study intergroup variation existed molecular-phylogenetic characterization custom phylogenetic microarray van erpecum kj van mil sw lower tmao levels human gut microbiome
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