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Title[redir]:
Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats - PMC
Description:
Maternal obesity and overnutrition during pregnancy and lactation can program an increased risk of obesity in offspring. In this context, improving maternal metabolism may help reduce the intergenerational transmission of obesity. Here we show that, ...
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Keywords {π}
maternal, offspring, dams, ofs, gut, hfs, doi, pubmed, google, scholar, obesity, lactation, diet, body, microbiota, weight, gestation, increased, obese, metabolic, group, metabolism, glp, pregnancy, highfatsucrose, day, pmc, analysis, oligofructose, microbial, abundance, article, spp, rats, groups, free, intake, fat, composition, effect, metabolites, data, insulin, weaning, relative, profiles, serum, glucose, prebiotic, levels,
Topics {βοΈ}
high-fat/sucrose diet-induced obesity14 high-fat/sucroseβ+β10% wt/wt oligofructose high-fat/sucrose diet supplemented restricted high-fat/sucrose feeding high-fat/sucrose ad libitum maternal high-fat/sucrose diet high-fat/sucrose diet provided independent-samples kruskall-wallis test high-fat/sucrose-fed females high-fat/sucrose diet obese sprague-dawley rat branched-chain amino acids orexigenic npy/agrp neurons pmc beta search high-fat maternal diet opls-da model fit male sprague-dawley rats higher myo-inositol levels diet-induced obese rats life-long obesity risk pair-wise orthogonal partial diet-induced obese dams hepatic fatty-acid oxidation k-fold cross-validation diet-induced maternal obesity sprague-dawley rats 05b bacteroides/prevotella spp maternal cross-sectional data additional information excess body fat nserc doctoral scholarship cross-sectional offspring outcomes lower brain-hedonic responses pre-pregnancy body weight appetite-reducing satiety hormone 1038/srep20683 diet-induced obesity-induced insulin resistance increased myo-inositol satiety hormones peptide-yy opls-da modeling long-term impact license information pmcid 1h nmr metabolomics increased maternal-fetal transfer gestational weight gain opls-da analysis parametric pairwise analysis post-hoc tests regulates fat storage oligofructose supplemented diet
Questions {β}
- Can nutritional modulation of maternal intestinal microbiota influence the development of the infant gastrointestinal tractβ?
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