We are analyzing https://link.springer.com/article/10.1186/s12943-021-01466-9.

Title:
CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma | Molecular Cancer
Description:
Background Hepatocellular carcinoma (HCC) is among the most common forms of cancer and is associated with poor patient outcomes. The emergence of therapeutic resistance has hampered the efficacy of targeted treatments employed to treat HCC patients to date. In this study, we conducted a series of CRISPR/Cas9 screens to identify genes associated with synthetic lethality capable of improving HCC patient clinical responses. Methods CRISPR-based loss-of-function genetic screens were used to target 18,053 protein-coding genes in HCC cells to identify chemotherapy-related synthetic lethal genes in these cells. Synergistic effects were analyzed through in vitro and in vivo analyses, while related mechanisms were explored through RNA-seq and metabolomics analyses. Potential inhibitors of identified genetic targets were selected through high-throughput virtual screening. Results The inhibition of phosphoseryl-tRNA kinase (PSTK) was found to increase HCC cell sensitivity to chemotherapeutic treatment. PSTK was associated with the suppression of chemotherapy-induced ferroptosis in HCC cells, and the depletion of PSTK resulted in the inactivation of glutathione peroxidative 4 (GPX4) and the disruption of glutathione (GSH) metabolism owing to the inhibition of selenocysteine and cysteine synthesis, thus enhancing the induction of ferroptosis upon targeted chemotherapeutic treatment. Punicalin, an agent used to treat hepatitis B virus (HBV), was identified as a possible PSTK inhibitor that exhibited synergistic efficacy when applied together with Sorafenib to treat HCC in vitro and in vivo. Conclusions These results highlight a key role for PSTK as a mediator of resistance to targeted therapeutic treatment in HCC cells that functions by suppressing ferroptotic induction. PSTK inhibitors may thus represent ideal candidates for overcoming drug resistance in HCC.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pstk, hcc, cells, fig, cell, ferroptosis, gpx, article, treatment, pubmed, sorafenib, knockout, genes, levels, resistance, google, scholar, cas, cancer, expression, analyses, tumor, pstkko, samples, targeted, lines, results, gsh, significantly, punicalin, death, inhibitors, selenocysteine, therapy, erastin, central, hepatocellular, carcinoma, biosynthesis, groups, patients, screening, inhibition, induction, significant, abemaciclib, control, study, identified, treated,

Topics {✒️}

powerful gene-editing technology punicalin-induced pstk/gpx4 deficiency crispr/cas9 knockout screens dual-sgrna plasmid construct article download pdf genotype-specific cancer liabilities s-appt induces ferroptosis kaplan-meier curves demonstrating high-throughput functional genomics pstk-nc/pstk-ko cells punicalin-induced cell death high-throughput virtual screening resultant hep3b-cas9 cells immunohistochemistry auto-stainer approach specifically phosphorylates seryl-trna o-phosphoseryl-trna kinase pstk-regulated cell death structure-based virtual screen crispr/cas9 screens nature reviews genetics ferroptosis-induced tumor eradication sorafenib-induced cell death pstk/sod2 high/medium expression pan-cancer tcga analysis ifn-γ-induced ferroptosis identified phosphoseryl-trna kinase xenograft-bearing mice treated targeted therapy-induced ferroptosis punicalin/geraniin/vehicle treated mice punicalin/geraniin/vehicle treatment groups protein-protein interaction networks paired t-test key ferroptosis-related genes approved multi-kinase inhibitor pstk-ko hcc cells pstk-sgrna1-sgrna2 construct pstk-specific sgrna sequences hep3b-pstk-ko cells pstk-ko hep3b cells genome-wide mapping hcc-specific therapeutic target treating pstk-ko cells full access crispr screening results generated pstk-ko cells recovering pstk/gpx4 expressions pstk slightly inhibited selenocysteine-dependent regulatory mechanism increasing abemaciclib/sorafenib concentrations control sgrna-transfected cells

Questions {❓}

CDK4/6 inhibition and sorafenib: a menage a deux in HCC therapy?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma
         description:Hepatocellular carcinoma (HCC) is among the most common forms of cancer and is associated with poor patient outcomes. The emergence of therapeutic resistance has hampered the efficacy of targeted treatments employed to treat HCC patients to date. In this study, we conducted a series of CRISPR/Cas9 screens to identify genes associated with synthetic lethality capable of improving HCC patient clinical responses. CRISPR-based loss-of-function genetic screens were used to target 18,053 protein-coding genes in HCC cells to identify chemotherapy-related synthetic lethal genes in these cells. Synergistic effects were analyzed through in vitro and in vivo analyses, while related mechanisms were explored through RNA-seq and metabolomics analyses. Potential inhibitors of identified genetic targets were selected through high-throughput virtual screening. The inhibition of phosphoseryl-tRNA kinase (PSTK) was found to increase HCC cell sensitivity to chemotherapeutic treatment. PSTK was associated with the suppression of chemotherapy-induced ferroptosis in HCC cells, and the depletion of PSTK resulted in the inactivation of glutathione peroxidative 4 (GPX4) and the disruption of glutathione (GSH) metabolism owing to the inhibition of selenocysteine and cysteine synthesis, thus enhancing the induction of ferroptosis upon targeted chemotherapeutic treatment. Punicalin, an agent used to treat hepatitis B virus (HBV), was identified as a possible PSTK inhibitor that exhibited synergistic efficacy when applied together with Sorafenib to treat HCC in vitro and in vivo. These results highlight a key role for PSTK as a mediator of resistance to targeted therapeutic treatment in HCC cells that functions by suppressing ferroptotic induction. PSTK inhibitors may thus represent ideal candidates for overcoming drug resistance in HCC.
         datePublished:2022-01-04T00:00:00Z
         dateModified:2022-01-04T00:00:00Z
         pageStart:1
         pageEnd:17
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12943-021-01466-9
         keywords:
            Hepatocellular carcinoma
            CRISPR library screening
            PSTK
            Ferroptosis
            Cancer Research
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig7_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig8_HTML.png
         isPartOf:
            name:Molecular Cancer
            issn:
               1476-4598
            volumeNumber:21
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yiran Chen
               affiliation:
                     name:Peking University Cancer Hospital and Institute
                     address:
                        name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Li Li
               affiliation:
                     name:Peking University International Hospital
                     address:
                        name:Department of Oncology, Peking University International Hospital, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jie Lan
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yang Cui
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaosong Rao
               affiliation:
                     name:Boao Evergrande International Hospital
                     address:
                        name:Department of Pathology, Boao Evergrande International Hospital, Qionghai, China
                        type:PostalAddress
                     type:Organization
                     name:Peking University International Hospital
                     address:
                        name:Department of Pathology, Peking University International Hospital, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jing Zhao
               affiliation:
                     name:The Affiliated Hospital of Qingdao University, Qingdao University
                     address:
                        name:Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tao Xing
               affiliation:
                     name:Peking University Cancer Hospital and Institute
                     address:
                        name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gaoda Ju
               affiliation:
                     name:Peking University Cancer Hospital and Institute
                     address:
                        name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Guangtao Song
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
                     address:
                        name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jizhong Lou
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jun Liang
               affiliation:
                     name:Peking University Cancer Hospital and Institute
                     address:
                        name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                        type:PostalAddress
                     type:Organization
                     name:Peking University International Hospital
                     address:
                        name:Department of Oncology, Peking University International Hospital, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma
      description:Hepatocellular carcinoma (HCC) is among the most common forms of cancer and is associated with poor patient outcomes. The emergence of therapeutic resistance has hampered the efficacy of targeted treatments employed to treat HCC patients to date. In this study, we conducted a series of CRISPR/Cas9 screens to identify genes associated with synthetic lethality capable of improving HCC patient clinical responses. CRISPR-based loss-of-function genetic screens were used to target 18,053 protein-coding genes in HCC cells to identify chemotherapy-related synthetic lethal genes in these cells. Synergistic effects were analyzed through in vitro and in vivo analyses, while related mechanisms were explored through RNA-seq and metabolomics analyses. Potential inhibitors of identified genetic targets were selected through high-throughput virtual screening. The inhibition of phosphoseryl-tRNA kinase (PSTK) was found to increase HCC cell sensitivity to chemotherapeutic treatment. PSTK was associated with the suppression of chemotherapy-induced ferroptosis in HCC cells, and the depletion of PSTK resulted in the inactivation of glutathione peroxidative 4 (GPX4) and the disruption of glutathione (GSH) metabolism owing to the inhibition of selenocysteine and cysteine synthesis, thus enhancing the induction of ferroptosis upon targeted chemotherapeutic treatment. Punicalin, an agent used to treat hepatitis B virus (HBV), was identified as a possible PSTK inhibitor that exhibited synergistic efficacy when applied together with Sorafenib to treat HCC in vitro and in vivo. These results highlight a key role for PSTK as a mediator of resistance to targeted therapeutic treatment in HCC cells that functions by suppressing ferroptotic induction. PSTK inhibitors may thus represent ideal candidates for overcoming drug resistance in HCC.
      datePublished:2022-01-04T00:00:00Z
      dateModified:2022-01-04T00:00:00Z
      pageStart:1
      pageEnd:17
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12943-021-01466-9
      keywords:
         Hepatocellular carcinoma
         CRISPR library screening
         PSTK
         Ferroptosis
         Cancer Research
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig7_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-021-01466-9/MediaObjects/12943_2021_1466_Fig8_HTML.png
      isPartOf:
         name:Molecular Cancer
         issn:
            1476-4598
         volumeNumber:21
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yiran Chen
            affiliation:
                  name:Peking University Cancer Hospital and Institute
                  address:
                     name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li Li
            affiliation:
                  name:Peking University International Hospital
                  address:
                     name:Department of Oncology, Peking University International Hospital, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jie Lan
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yang Cui
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaosong Rao
            affiliation:
                  name:Boao Evergrande International Hospital
                  address:
                     name:Department of Pathology, Boao Evergrande International Hospital, Qionghai, China
                     type:PostalAddress
                  type:Organization
                  name:Peking University International Hospital
                  address:
                     name:Department of Pathology, Peking University International Hospital, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jing Zhao
            affiliation:
                  name:The Affiliated Hospital of Qingdao University, Qingdao University
                  address:
                     name:Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tao Xing
            affiliation:
                  name:Peking University Cancer Hospital and Institute
                  address:
                     name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gaoda Ju
            affiliation:
                  name:Peking University Cancer Hospital and Institute
                  address:
                     name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guangtao Song
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
                  address:
                     name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jizhong Lou
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jun Liang
            affiliation:
                  name:Peking University Cancer Hospital and Institute
                  address:
                     name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
                     type:PostalAddress
                  type:Organization
                  name:Peking University International Hospital
                  address:
                     name:Department of Oncology, Peking University International Hospital, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Molecular Cancer
      issn:
         1476-4598
      volumeNumber:21
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Peking University Cancer Hospital and Institute
      address:
         name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
         type:PostalAddress
      name:Peking University International Hospital
      address:
         name:Department of Oncology, Peking University International Hospital, Beijing, China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Boao Evergrande International Hospital
      address:
         name:Department of Pathology, Boao Evergrande International Hospital, Qionghai, China
         type:PostalAddress
      name:Peking University International Hospital
      address:
         name:Department of Pathology, Peking University International Hospital, Beijing, China
         type:PostalAddress
      name:The Affiliated Hospital of Qingdao University, Qingdao University
      address:
         name:Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China
         type:PostalAddress
      name:Peking University Cancer Hospital and Institute
      address:
         name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
         type:PostalAddress
      name:Peking University Cancer Hospital and Institute
      address:
         name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
      address:
         name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Peking University Cancer Hospital and Institute
      address:
         name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
         type:PostalAddress
      name:Peking University International Hospital
      address:
         name:Department of Oncology, Peking University International Hospital, Beijing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yiran Chen
      affiliation:
            name:Peking University Cancer Hospital and Institute
            address:
               name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
               type:PostalAddress
            type:Organization
      name:Li Li
      affiliation:
            name:Peking University International Hospital
            address:
               name:Department of Oncology, Peking University International Hospital, Beijing, China
               type:PostalAddress
            type:Organization
      name:Jie Lan
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yang Cui
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Xiaosong Rao
      affiliation:
            name:Boao Evergrande International Hospital
            address:
               name:Department of Pathology, Boao Evergrande International Hospital, Qionghai, China
               type:PostalAddress
            type:Organization
            name:Peking University International Hospital
            address:
               name:Department of Pathology, Peking University International Hospital, Beijing, China
               type:PostalAddress
            type:Organization
      name:Jing Zhao
      affiliation:
            name:The Affiliated Hospital of Qingdao University, Qingdao University
            address:
               name:Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China
               type:PostalAddress
            type:Organization
      name:Tao Xing
      affiliation:
            name:Peking University Cancer Hospital and Institute
            address:
               name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
               type:PostalAddress
            type:Organization
      name:Gaoda Ju
      affiliation:
            name:Peking University Cancer Hospital and Institute
            address:
               name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
               type:PostalAddress
            type:Organization
      name:Guangtao Song
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
            address:
               name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jizhong Lou
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jun Liang
      affiliation:
            name:Peking University Cancer Hospital and Institute
            address:
               name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
               type:PostalAddress
            type:Organization
            name:Peking University International Hospital
            address:
               name:Department of Oncology, Peking University International Hospital, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
      name:Department of Oncology, Peking University International Hospital, Beijing, China
      name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
      name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
      name:Department of Pathology, Boao Evergrande International Hospital, Qionghai, China
      name:Department of Pathology, Peking University International Hospital, Beijing, China
      name:Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China
      name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
      name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
      name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
      name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
      name:Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
      name:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Oncology, Peking University Cancer Hospital and Institute, Beijing, P.R. China
      name:Department of Oncology, Peking University International Hospital, Beijing, China

External Links {🔗}(156)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Knockout.js
Prism.js

CDN Services {📦}

Crossref

4.53s.

LINK . SPRINGER . COM {}