We are analyzing https://link.springer.com/article/10.1186/s12943-019-1109-9.

Title:
Functions of N6-methyladenosine and its role in cancer | Molecular Cancer
Description:
N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR. In this review, we elaborate on recent advances in research of m6A enzymes. We also highlight the underlying mechanism of m6A in cancer pathogenesis and progression. Finally, we review corresponding potential targets in cancer therapy.
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Keywords {🔍}

pubmed, article, google, scholar, cancer, cas, cell, rna, mettl, central, expression, wang, mrna, zhang, methylation, promotes, liu, chen, translation, tumor, ythdf, modification, cells, carcinoma, res, progression, mol, proliferation, nmethyladenosine, yang, target, fto, enhances, regulates, genes, huang, role, level, protein, gene, regulation, zhou, methyladenosine, degradation, inhibits, igfbp, binding, oncogene, zhao, human,

Topics {✒️}

aff4/nf-kappab/myc signaling network fto-pgc-1alpha signalling axis m6a-hur-dependent epigenetic silencing mettl3-mediated n6-methyladenosine modification rna n6-methyladenosine-related genes article download pdf mrna-binding factor rbm15/spenito gas6-axl signaling network fetal–adult hematopoietic switch anti-tumour immunity controlled mir-33a suppresses proliferation n6-methyladenosine rna methylation ythdf2-dependent posttranscriptional silencing fak/pi3k/akt pathway [139] a-dependent translation control rna n6-methyladenosine methyltransferase rna n6-methyladenosine methyltransferase rna n6-methyladenosine modification rna modification n6-methyladenosine hypoxia/reoxygenation -treated cardiomyocytes hypoxia/reoxygenation-treated cardiomyocytes inhibit nf-kappab activity n6-methyladenosine-dependent regulation important methyl-group donor sponge mir-590-3p/mir-1275 impaired ythdf2-directed-degradation anti-tumor immune response inhibited ythdf1-mediated-tranlation a-cdcp1 signaling axis wtap–wt1–tbl1 axis [161] wtap-wt1-tbl1 axis /α-ketoglutarate-dependent dioxygenases excessive mir-25-3p maturation machinery component wtap/fl rna-binding protein lin28b lin28b-induced hematopoietic reprogramming mrna cap-binding protein myocardin-related transcription factors counteracting trim21-mediated ubiquitination small-cell lung carcinoma mir-33a decreases expression a-ythdf2 dependent mechanism suppressing ythdf2-mediated-degradation promotes cap-independent translation central south university alkbh5-directed m6a demethylation mettl16 regulates s-adenosylmethionine a-igf2bp2-dependent mechanism mettl3-eif3h enhances translation impairing mirna-directed downregulation

Questions {❓}

SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

Schema {🗺️}

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         headline:Functions of N6-methyladenosine and its role in cancer
         description:N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR. In this review, we elaborate on recent advances in research of m6A enzymes. We also highlight the underlying mechanism of m6A in cancer pathogenesis and progression. Finally, we review corresponding potential targets in cancer therapy.
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      headline:Functions of N6-methyladenosine and its role in cancer
      description:N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR. In this review, we elaborate on recent advances in research of m6A enzymes. We also highlight the underlying mechanism of m6A in cancer pathogenesis and progression. Finally, we review corresponding potential targets in cancer therapy.
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