
NCBI . NLM . NIH . GOV {
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Title[redir]:
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor - PMC
Description:
S-adenosylmethionine (SAM) is an essential metabolite that acts as a cofactor for most methylation events in the cell. The N6-methyladenosine (m6A) methyltransferase METTL16 controls SAM homeostasis by regulating the abundance of SAM synthetase ...
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Keywords {🔍}
mettl, rna, sam, activity, methylation, figure, scholar, google, doi, pubmed, mata, shown, complex, region, pmc, article, binding, structure, mrna, data, free, mutations, vitro, transition, substrate, paper, sequence, kloop, figures, structural, catalytic, cell, methyltransferase, levels, loop, cells, mettlmettl, mtd, plasmid, pendleton, structures, efficiency, protein, hairpins, conformation, molecular, pocket, utr, consensus, wildtype,
Topics {✒️}
energy contract de-ac02–06ch11357 uk/personal/pemsley/coot/ phaser table s2 nihms1004023-supplement-table_s2 ab_259529 mouse anti-actin murine s-adenosylmethionine synthetase rna-binding-competent n184a mutation [google scholar] linder pmc beta search high-energy methyl donor asn-pro-pro-phe comprehensive python-based system single-wavelength anomalous dispersion methionine-free media supplemented american cancer society/harold n-terminal ccch motifs genome-wide sequencing experiments selective n6-adenosine methylation supplementary materials included ccch zinc-binding motifs radiolabeled α- 32p-utp size-exclusion chromatography coupled double-stranded rna adjacent histone h3-induced activation nuclear noncoding rna methionine-free dmem met-free media single-nucleotide-resolution mapping n6-methyladenosine methyltransferase mettl16 m167a—dramatically activate methylation sam-hypersensitive k163a mutation spring-loaded base modification ura9-ade19 base pair mettl16-rna complex—k163a endowed scholar program tet-free fbs plasmid β mat-wt steady-state mat2a mrna incorporated 3h-methyl group full-length mettl16 construct fl mettl3/mettl14 wt loop/transition region modulates maximize sequence-specific contacts intra-cellular sam concentrations k-loop transform mettl16 martínez-chantar m6a-dependent degradation mettl16-hp1x complex exhibits star★methods contact references adams pd methyltransferase complex mettl3/mettl14
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