
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Trabectedin, a drug acting on both cancer cells and the tumour microenvironment - PMC
Description:
Trabectedin is the first marine-derived anti-neoplastic drug approved for the treatment of advanced soft tissue sarcoma and, in combination with pegylated liposomal doxorubicin, for the treatment of patients with relapsed platinum-sensitive ovarian ...
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {🔍}
doi, trabectedin, google, scholar, pubmed, cancer, cells, tumour, dincalci, dna, pmc, transcription, effects, article, sarcoma, free, galmarini, activity, mechanisms, myxoid, grohar, drug, allavena, treatment, tme, sanfilippo, casali, patients, grosso, ecteinascidin, action, macrophages, repair, effect, mantovani, advanced, nlm, microenvironment, drugs, erba, cell, damia, liposarcoma, germano, helman, clinical, response, antitumor, res, oncol,
Topics {✒️}
transcription-coupled nucleotide-excision repair inter-strand cross-linking lesion von hippel-lindau-coupled pmc beta search fus-chop chimaera variants fusion proteins fus-chop xpf-dependent dna breaks [google scholar] damia fus-chop expression influences bueren-calabuig ja macrophage pro-tumoral functions nucleotide excision repair classical dna-damaging agents translocation-related sarcomas effects double-stranded dna anti-neoplastic drugs acting trabectedin affects trans-activated soft tissue sarcoma size-based response criteria trabectedin-induced dna damage showed anti-tumour activity dna-repair pathways oncogenic transcription factor significant anti-tumour effect dna repair functionality pro-tumoral functions recurrent uterine leiomyosarcoma advanced uterine leiomyosarcomas publisher site pdf dna repair mechanisms gene-dependent manner myxoid liposarcoma tumors trans-activated transcription license information pmcid bueren-calabuig targeting dna repair myxoid liposarcoma xenografts rna polymerase ii pmc disclaimer gynecologic oncology group transcription factor cofactors prolonged anti-inflammatory type iii chimaera sousa-faro jm natural marine compound ews-fli1 protein recurrent ovarian cancer myxoid liposarcoma cells werner syndrome protein restraining cancer progression
Questions {❓}
- Why don't we get more cancer?
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