
NCBI . NLM . NIH . GOV {
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Title[redir]:
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation - PMC
Description:
The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4+CD25+ regulatory T cells (T reg cells) expressing FoxP3 and exhibiting ...
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Keywords {🔍}
cells, reg, tumor, cell, proliferation, tgfβ, imdcs, fig, cdcd, tbr, dcs, pubmed, google, scholar, mice, rats, doi, regulatory, vivo, tfr, prob, isolated, tumors, tumorbearing, dlns, spleen, cdb, pmc, free, splenic, data, brdu, sem, represent, mhc, class, rat, vitro, bearing, article, tumorfree, tfm, determined, values, test, purified, shown, tgfβrii, produce, lns,
Topics {✒️}
org/cgi/content/full/jem neutralizing anti–tgf-β antibody polyclonal anti–tgf-β antibody tgf-β curtails imdc-driven anti–tgf-β antibody significantly anti-cd3 mab–driven proliferation anti–tgf-β1 blocking antibodies tumor-bearing bd-ix rats antigen–specific ifn-γ secretion forkhead/winged-helix protein dn tgf-βrii transgene anti-mitotic drug releases β receptor ii nf-κb signaling pathway dn tgf-βrii mice 10 ng/ml tgf-β1 1 ng/ml tgf-β1 secrete bioactive tgf-β tgf-β–dependent manner tgf-βrii–dependent fashion mouse cd3–cy-chrome immunocompetent bd-ix rats tgf-β–dependent fashion exogenous tgf-β cooperates pmc beta search pmc copyright notice induced tgf-β production anti–rat cd25 antibody late-stage ovarian cancer tumor-free mouse/mice fbs-free medium supplemented serum-free rpmi medium tumor-free animals received transforming growth factor exogenous tgf-β failed mixed tumor/lymphocyte cultures isolating tumor-infiltrating cd25+ antigen-processing dendritic cells tumor-draining lymph nodes cd3+cd4+cd25+ cells isolated tgf-β–expressing cells tumor-infiltrating macrophages recruit actively produce tgf-β toll pathway-dependent blockade anti–rat cd25 mab drive tgf-β–dependent mhc class ii cd11c magnetic beads increased ifn-γ secretion dc-infiltrated lymphoid organs
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