We are analyzing https://link.springer.com/article/10.1186/s12943-017-0596-9.

Title:
Epigenetics in cancer stem cells | Molecular Cancer
Description:
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key mechanisms by which epigenetic regulation contribute to cancer progression. In this review, we present a discussion of how deregulation of various epigenetic pathways can contribute to cancer initiation and tumorigenesis, particularly with respect to maintenance and survival of cancer stem cells. This information, together with several promising clinical and preclinical trials of epigenetic modulating drugs, offer new possibilities for targeting cancer stem cells as well as improving cancer therapy overall.
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Keywords {🔍}

pubmed, google, scholar, article, cas, cancer, cells, cell, central, histone, stem, epigenetic, tumor, methylation, inhibitor, expression, signaling, cscs, protein, inhibitors, dna, breast, gene, lysine, phase, leukemia, tumors, treatment, notch, methyltransferase, differentiation, genes, wang, patients, drug, study, pathway, inhibition, res, human, clinical, cancers, therapy, target, lung, found, biol, oncol, csc, activity,

Topics {✒️}

edward kai-hua chow stat3/p63/jagged/notch cascade gsk-3β targets β-catenin human mll-af4 leukemias transforming growth factor-β e3-ubiquitin ligase complex transcription factor β-catenin article download pdf granule neuron progenitors/precursors cutaneous t-cell lymphoma human colon-cancer-initiating cells rna polymerase ii wnt/β-catenin pathway wnt/β-catenin pathway [44] serine-threonine kinase receptor wnt/β-catenin signaling pan-histone deacetylase inhibitor stem cell-based signature wnt/beta-catenin signaling histone-deacetylase inhibitor givinostat membrane protein e-cadherin e-cadherin repressors zeb1 bromo-adjacent homology domain smrt/ncor2 corepressor correlates stem/progenitor cell features cancer-related pathways affected triple-negative breast cancer mll-rearranged leukemia cells autologous stem-cell transplantation decreased cell-cell adhesion long-term gene silencing prostate stem/progenitor cells possess anti-proliferative effects anti-ctla-4 monoclonal antibody phase 1b-2a study e-cadherin promoter helps hedgehog protein-driven cancers bromodomain inhibitors i-bet151 ovarian cancer-initiating cells includes atp-binding cassette small-cell lung cancer mixed lineage leukemia h3k27me3-mediated chromatin remodelling csc-related signaling pathways identify tumor-initiating cells tamoxifen-resistant breast cancer nf-kappab activation triggered colorectal cancer-initiating cells 4 t1 tumor-bearing mice hsnf5/ini1 gene predispose

Questions {❓}

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?
LSD1 inhibition: a therapeutic strategy in cancer?
Therapeutic modulation of Notch signalling--are we there yet?
Will DNA methylation inhibitors work in solid tumors?

Schema {🗺️}

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         description:Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key mechanisms by which epigenetic regulation contribute to cancer progression. In this review, we present a discussion of how deregulation of various epigenetic pathways can contribute to cancer initiation and tumorigenesis, particularly with respect to maintenance and survival of cancer stem cells. This information, together with several promising clinical and preclinical trials of epigenetic modulating drugs, offer new possibilities for targeting cancer stem cells as well as improving cancer therapy overall.
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         DNA methylation
         Signaling pathway
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         Oncology
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