
NCBI . NLM . NIH . GOV {
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Title[redir]:
Targeting the Unique Methylation Pattern of Androgen Receptor (AR) Promoter in Prostate Stem/Progenitor Cells with 5-Aza-2โฒ-deoxycytidine (5-AZA) Leads to Suppressed Prostate Tumorigenesis - PMC
Description:
Background: There is a specific silencing of AR gene expression in prostate stem cells. Results: The induction of AR gene expression inhibited the self-renewal of the prostate stem cells. Conclusion: The induction of AR expression suppressed PCa ...
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Keywords {๐}
cells, stemprogenitor, prostate, expression, stem, pubmed, google, scholar, cell, doi, aza, cancer, methylation, pca, promoter, fig, pmc, lncap, article, pcscs, cpg, mpre, normal, differentiation, human, free, dna, types, pcr, treatment, mice, androgen, receptor, results, prostatepca, mouse, shown, assay, selfrenewal, methylated, induction, embryonic, tumor, treated, analysis, analyzed, mbd, mrna, chang, protein,
Topics {โ๏ธ}
excellence grant doh99-td-b-111-004 transit-amplifying cells/intermediate cells stem/progenitor cell-specific therapy normal prostate/prostate cancer promotes stem/progenitor cells bio-rad cfx96 system luminal cell-type cytokeratins malignant cancer-initiating cells pca stem/progenitor cells methyl-cpg-binding protein mbd2 prostate stem/progenitor cells prostate cancer stem/progenitor simultaneously suppress stem/progenitor htert-immortalized primary nonmalignant cd44+ฮฑ2ฮฒ1+ cell population targeting stem/progenitor cells pmc beta search driving stem/progenitor cells lncap stem/progenitor cells hrp-conjugated anti-rabbit pcsc-derived tumor formation target stem/progenitor cells stem/progenitor cell markers small-cell lung carcinoma prostate tumor-initiating cells drive stem/progenitor cells pmc copyright notice dihydrotestosterone tissue levels cd133+/cd44+ wpe1-nb26 affecting ar-mediated proliferation asc-j9 ameliorates spinal quantitative rt-pcr 5% fat-free milk unmethylated sulfite-modified sequence rna-methyltransferase misu bisulfite-modified dnas isolated stem/progenitor cell types human prostate epithelium bisulfite-specific pcr protein g-agarose columns mouse normal prostatic pca cell lines androgen receptor signaling stem/progenitor cell pca stem cells epitectยฎ bisulfite kit prostate stem cells human prostate cancer stem/progenitor cells stem/progenitor cells
Questions {โ}
- (2003) Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?
- A new paradigm in immunotherapy?
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