
NCBI . NLM . NIH . GOV {
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Title[redir]:
Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors - PMC
Description:
The objective of this study was to identify and characterize a self-renewing subpopulation of human ovarian tumor cells (ovarian cancer-initiating cells, OCICs) fully capable of serial propagation of their original tumor phenotype in animals. ...
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Keywords {🔍}
cells, doi, tumor, ovarian, cancer, cell, stem, tumors, google, scholar, pubmed, spheroids, cdcd, ocics, conditions, sphereforming, fig, human, expression, primary, epithelial, xenograft, bottom, cics, tumorigenic, spheroid, left, similar, mouse, res, injection, markers, ascites, patient, mice, table, pmc, phenotype, differentiating, surface, dissociated, cellselective, top, highly, subpopulation, growth, progenitors, differentiation, bulk, facs,
Topics {✒️}
serum-free dmem/f12 supplemented polyclonal anti-nanog/anti—oct-4 antibodies fitc-conjugated secondary antibody sf1 nihms58774-supplement-sf1 sf2 nihms58774-supplement-sf2 st1 nihms58774-supplement-st1 st2 nihms58774-supplement-st2 st3 nihms58774-supplement-st3 pe-conjugated secondary antibody carcinoma-derived cell lines gene-specific primer sequences post—sort flow cytometry xenograft-passaged cd44+cd117+ cells tumor-infiltrating mouse cells adherent sphere-forming cells sphere-forming cells express fluorescence-activated cell sorting purified cd44+cd117+ cells müllerian duct—derived endometrium balb/ c-nu/nu sphere-forming cells derived pmc beta search stem cell—selective conditions stem cell–selective conditions dmem/f12 medium stem/progenitor cell properties cancer stem cells-perspectives t2 sphere-forming cells müllerian inhibiting substance serum-free medium ovarian cancer-initiating cells anti-cd44 monoclonal antibodies anti-cd117 monoclonal antibodies reverse transcription—pcr analysis autocrine scf/cd117 cascade stem cell factor sphere-forming ocics derived sphere-forming cells overexpressed sphere-forming cells ”ocics” t5 sphere-forming cells drug-free medium mouse nonspecific igg multi-lineage progenitor cells ovulation-induced inflammatory responses early tumor initiation/progression showed cd44+cd117+ cells highly neo-plastic progenitors nontumorigenic cd44−cd117− cells t3 cd44+cd117+ cells drug-resistant tumors invokes
Questions {❓}
- Nestin expression-a property of multi-lineage progenitor cells?
- The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes?
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