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Ferroptosis as an important driver of lupus | Protein & Cell
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Keywords {🔍}
ferroptosis, sle, pubmed, neutrophil, article, gpx, death, cell, neutrophils, ifnα, google, scholar, lupus, serum, expression, lipid, central, cremα, cancer, cas, igg, mice, levels, systemic, role, cells, peroxidation, inhibitors, authors, erythematosus, glutathione, viability, increased, privacy, cookies, research, access, mao, form, immune, nuclear, mechanisms, disease, significantly, potential, autoantibodies, promote, binding, promoter, netosis,
Topics {✒️}
article download pdf tissue-specific transcriptional repressor calcium/calmodulin kinase iv dhodh-mediated ferroptosis defence li zhuang & boyi gan systemic lupus erythematosus lupus-prone mice promote sle pathogenesis garcia-romo privacy choices/manage cookies cremα nuclear translocation accelerated neutrophil death dysregulated neutrophil death regulating neutrophil death mediating neutrophil death increased nuclear translocation neutrophil ferroptosis remains promote cremα phosphorylation full access nonapoptotic cell death neutrophil extracellular trap cell death inhibitors cancer center support counteract lipid peroxidation increased lipid peroxidation inducing neutrophil ferroptosis increase ifnγ release reduced cystine uptake release large amounts toxic lipid alcohols induce neutrophil ferroptosis article mao ferroptosis remained unknown enhancing lipid oxidation abnormally low levels elevated gpx4 levels animal subjects performed protein cell 13 suppress gpx4 expression downregulating gpx4 expression gpx4 expression controlled regulating gpx4 expression cytokine array analyses sle serum samples sle serum activate european economic area cytoplasmic antigen exposure double-edged sword reactive oxygen species nadph oxidase complex
Questions {❓}
- So how is GPX4 expression controlled in this context?
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