We are analyzing https://link.springer.com/article/10.1007/s12035-018-1138-1.

Title:
m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases | Molecular Neurobiology
Description:
RNA modifications are involved in many aspects of biological functions. N6-methyladenosine (m6A) is one of the most important forms of RNA methylation and plays a vital role in regulating gene expression, protein translation, cell behaviors, and physiological conditions in many species, including humans. The dynamic and reversible modification of m6A is conducted by three elements: methyltransferases (“writers”), such as methyltransferase-like protein 3 (METTL3) and METTL14; m6A-binding proteins (“readers”), such as the YTH domain family proteins (YTHDFs) and YTH domain-containing protein 1 (YTHDC1); and demethylases (“erasers”), such as fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5). In this review, we summarize the current knowledge on mapping mRNA positions of m6A modification and revealing molecular processes of m6A. We further highlight the biological significance of m6A modification in neural cells during development of the nervous system and its association with human diseases. m6A RNA methylation is becoming a new frontier in neuroscience and should help us better understand neural development and neurological diseases from a novel point of view.
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Keywords {🔍}

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Topics {✒️}

targeting tsc1-mtor-tau signaling mrna-binding factor rbm15/spenito month download article/chapter xist rna-mediated silencing transcriptional n6-adenosine methylation rna modification n6-methyladenosine c-fos expression induced il-7/stat5/socs pathways n6-methyladenosine rna mark sex-specific splicing factor rna n6-methyladenosine methyltransferase n6-methyladenosine-dependent regulation n6-methyladenosine-modified rna dioxygenase-encoding fto gene fine-tuning gene expression post-transcriptional regulatory elements mammalian rna demethylase high-resolution mapping reveals full article pdf mrna methylation controls machinery component wtap/fl mettl3-mettl14 complex obesity-related fto gene obesity-related gene fto understand neural development m6a rna methylation single-stranded dna microprocessor complex mediates regulates alternative splicing n6-adenosine methylation messenger rna stability wilms’ tumor-1 protein rna demethylase alkbh5 methyladenosine methylated mrnas privacy choices/manage cookies article du revealing molecular processes experience-dependent accumulation m6a-binding proteins 2021 m6a-binding proteins eukaryotic ribosomal rna mis complex regulates influenza virus mrnas tumor-specific cytotoxic reversible rna modifications ythdf3 facilitates translation mammalian cortical neurogenesis impacts rna metabolism reader ythdf1 expression heat shock response

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         description:RNA modifications are involved in many aspects of biological functions. N6-methyladenosine (m6A) is one of the most important forms of RNA methylation and plays a vital role in regulating gene expression, protein translation, cell behaviors, and physiological conditions in many species, including humans. The dynamic and reversible modification of m6A is conducted by three elements: methyltransferases (“writers”), such as methyltransferase-like protein 3 (METTL3) and METTL14; m6A-binding proteins (“readers”), such as the YTH domain family proteins (YTHDFs) and YTH domain-containing protein 1 (YTHDC1); and demethylases (“erasers”), such as fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5). In this review, we summarize the current knowledge on mapping mRNA positions of m6A modification and revealing molecular processes of m6A. We further highlight the biological significance of m6A modification in neural cells during development of the nervous system and its association with human diseases. m6A RNA methylation is becoming a new frontier in neuroscience and should help us better understand neural development and neurological diseases from a novel point of view.
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         Cell Biology
         Neurology
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