We are analyzing https://link.springer.com/article/10.1007/s00281-016-0583-z.

Title:
Dendritic cells as gatekeepers of tolerance | Seminars in Immunopathology
Description:
Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune responses. In particular, they are considered as the most potent antigen presenting cells, governing both T cell immunity and tolerance. In view of their exceptional ability to present antigen and to interact with T cells, DC play distinct roles in shaping T cell development, differentiation and function. The outcome of the DC-T cell interaction is determined by the state of DC maturation, the type of DC subset, the cytokine microenvironment and the tissue location. Both regulatory T cells (Tregs) and DC are indispensable for maintaining central and peripheral tolerance. Over the past decade, accumulating data indicate that DC critically contribute to Treg differentiation and homeostasis.
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Keywords {🔍}

pubmed, cells, article, google, scholar, cas, dendritic, central, immunol, cell, regulatory, immunity, med, tolerance, exp, nat, development, mice, induce, receptor, differentiation, peripheral, induction, plasmacytoid, vivo, tolerogenic, foxp, function, homeostasis, autoimmune, antigen, rev, autoimmunity, ligand, blood, proc, natl, acad, sci, signaling, immune, type, science, activation, tgfbeta, clausen, responses, human, cdalpha, arthritis,

Topics {✒️}

month download article/chapter e-cadherin-mediated adhesion induces girard-madoux mj transforming growth factor-beta tolerogenic cd11c + cd11b + dendritic cells transcription factor c-maf tcr-induced stop signal cd8alpha + conventional dendritic cells melanoma-antigen-specific anergy established collagen-induced arthritis dendritic cell-specific deletion irf8-dependent dendritic cells dendritic cell-based immunotherapy dendritic cell-based interventions retinoic acid-dependent mechanism aryl hydrocarbon receptor cell receptor zeta-chain fewer regulatory t-cells icos-icos-ligand pathway collagen-induced arthritis mice cd8alpha-11b + dendritic cells b7-h1-deficiency enhances human clinical-applicable dc dendritic cell-mediated cd4+ thyroglobulin-specific cd4 + cd25+ plasmacytoid-derived dendritic cells semi-mature dendritic cells dendritic cell-specific disruption pd-l1 promote tolerance langerhans cell-derived il-10 cell-dendritic cell interactions peripheral lymphoid tissues mt1-mmp-dependent activation fatal early-onset autoimmunity steady-state dendritic cells il-10-producing tr1 cells full article pdf antigen-processing dendritic cells tolerance review published adaptive immune responses beta-catenin balances immunity peripheral cd4 + cd25- naive semimature dendritic cells conventional dendritic cells adaptive foxp3 + cd4+ regulatory tumor-induced tolerance experimental autoimmune encephalomyelitis costimulatory receptor icos kel jm collagen-induced arthritis

Questions {❓}

(2011) Human dendritic cell deficiency: the missing ID?
Clausen BE, Kel JM (2010) Langerhans cells: critical regulators of skin immunity?

Schema {🗺️}

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         description:Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune responses. In particular, they are considered as the most potent antigen presenting cells, governing both T cell immunity and tolerance. In view of their exceptional ability to present antigen and to interact with T cells, DC play distinct roles in shaping T cell development, differentiation and function. The outcome of the DC-T cell interaction is determined by the state of DC maturation, the type of DC subset, the cytokine microenvironment and the tissue location. Both regulatory T cells (Tregs) and DC are indispensable for maintaining central and peripheral tolerance. Over the past decade, accumulating data indicate that DC critically contribute to Treg differentiation and homeostasis.
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