
NCBI . NLM . NIH . GOV {
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Title[redir]:
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1 - PMC
Description:
Întegrins, matrix metalloproteases (MMPs), and the cytokine TGF-β have each been implicated in homeostatic cell behaviors such as cell growth and matrix remodeling. TGF-β exists mainly in a latent state, and a major point of homeostatic control is ...
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Keywords {🔍}
cells, tgfβ, cell, αvβ, activation, lapβ, mtmmp, fig, surface, pubmed, google, scholar, βexpressing, doi, mocktransduced, αvβmediated, active, antibodies, integrin, expression, growth, domain, data, munger, activity, antiβ, cytoplasmic, nishimura, slc, mmp, tmlc, shown, binding, mechanism, cambier, peptide, secreted, presence, rgd, μgml, determined, control, mutant, compared, expressed, subunit, affinity, antibody, absence, substrate,
Topics {✒️}
mt1-mmp–gfp–expressing ht1080 cells mt1-mmp–gfp fusion protein mt1-mmp–deficient h1264 cells hrp-conjugated sheep anti–mouse identical lap-β1–sepharose columns mt1-mmp–expressing h1264 cells mt1-mmp-expressing h1264 cells untreated mt1-mmp–expressing cells mt1-mmp–transduced h1264 cells mt1-mmp–gfp–expressing cells anti–tgf-β–blocking antibody anti-β8–blocking monoclonal antibody δmt1-mmp–expressing h1264 cells transforming growth factor-beta δmt1-mmp–transduced h1264 cells anti–tgf-β–blocking antibodies pan–tgf-β neutralizing antibody mt1-mmp–expressing h1264s cells anti–mt1-mmp monoclonal antibody transforming growth factor-β mt1-mmp–specific primers demonstrates transforming growth factor-β1 pmc beta search rhodamine donkey anti–rabbit commercial anti–mt1-mmp antibodies cd44-deficient mice develop β8-mediated tgf-β activation mt1-mmp fusion construct tgf-β3 isoform-specific antibodies αvβ8-mediated tgf-β activation chimeric pcdnaiβ8/3neo construct affinity purified anti–tgf-β1 phycoerythrin goat anti–mouse rhodamine goat anti–mouse bspe1-xho1 placental fragment gfp-expressing ht1080 cells activates latent tgf-β1 mock-transduced h1264 cells rabbit anti–mt1-mmp klenow-treated bamhi site biotinylated sheep anti–mouse phycoerythrin-conjugated secondary antibodies β8-expressing cells contained αvβ8 activates tgf-β1 tgf-β characteristically induces polyclonal anti-β8 antiserum mock-transduced ht1080 cells hpai mt1-mmp fragment surface-labeled sw480 cells bio-rad laboratories
Questions {❓}
- How does MT1-MMP interact with the αvβ8–TGF-β1 complex?
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