We are analyzing https://link.springer.com/article/10.1007/s00281-013-0409-1.

Title:
From proliferation to proliferation: monocyte lineage comes full circle | Seminars in Immunopathology
Description:
Monocytes are mononuclear circulating phagocytes that originate in the bone marrow and give rise to macrophages in peripheral tissue. For decades, our understanding of monocyte lineage was bound to a stepwise model that favored an inverse relationship between cellular proliferation and differentiation. Sophisticated molecular and surgical cell tracking tools have transformed our thinking about monocyte topo-ontogeny and function. Here, we discuss how recent studies focusing on progenitor proliferation and differentiation, monocyte mobilization and recruitment, and macrophage differentiation and proliferation are reshaping knowledge of monocyte lineage in steady state and disease.
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pubmed, google, scholar, cas, central, cell, cells, monocyte, macrophages, stem, van, macrophage, hematopoietic, atherosclerotic, atherosclerosis, mice, proliferation, monocytes, swirski, immunol, receptor, bone, biol, marrow, nat, lesions, differentiation, inflammatory, blood, nature, scavenger, science, sci, thromb, progenitor, factor, med, acad, libby, weissleder, arterioscler, vasc, article, immunity, frenette, rooijen, nahrendorf, pittet, human, res,

Topics {✒️}

month download article/chapter atp-binding cassette transporters oxidized-low-density-lipoprotein bone marrow-specific deficiency bone marrow-derived cells hmg-coa reductase inhibitor colony-stimulating factor combinations tumor necrosis factor-alpha apoe3-leiden transgenic mice diesselhoff-den dulk mm macrophage colony-stimulating factor haematopoietic stem-cell maintenance yolk sac-derived macrophages cxcl12-cxcr4 chemokine signaling transcriptional regulatory pathways receptor-mediated lipid uptake haematopoietic stem cells lymphoid mouse progenitors hematopoietic progenitor cells ldl receptor-deficient mice hematopoietic stem cells survey steady-state tissues de winther mp early mesenchymal progenitors ccr2−/− mice reveals progenitor cell mobilization scavenger receptor activity privacy choices/manage cookies independent chemokine functions apoe3leiden transgenic mice tissue-resident macrophages hanna rn massachusetts general hospital chemokine receptor ccr2 local macrophage proliferation monocyte-derived cells distinct functions atherosclerotic lesion formation atherosclerotic lesion development decreased lesion formation cell turnover characterizes adult microglia derive mutation reduces atherosclerosis chemokine receptor axes chemokine receptor ccr7 cell proliferation rates ccr2-mediated recruitment macrophage scavenger receptor double knockout mice myeloid cells independent

Questions {❓}

Coller BS (2005) Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?
Has our knowledge matured?

Schema {🗺️}

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         description:Monocytes are mononuclear circulating phagocytes that originate in the bone marrow and give rise to macrophages in peripheral tissue. For decades, our understanding of monocyte lineage was bound to a stepwise model that favored an inverse relationship between cellular proliferation and differentiation. Sophisticated molecular and surgical cell tracking tools have transformed our thinking about monocyte topo-ontogeny and function. Here, we discuss how recent studies focusing on progenitor proliferation and differentiation, monocyte mobilization and recruitment, and macrophage differentiation and proliferation are reshaping knowledge of monocyte lineage in steady state and disease.
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