
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Therapeutic siRNA silencing in inflammatory monocytes - PMC
Description:
Inflammatory monocytes -- but not the non-inflammatory subset -- depend on the chemokine receptor CCR2 for distribution to injured tissue and stimulate disease progression. Precise therapeutic targeting of this inflammatory monocyte subset could ...
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Keywords {🔍}
doi, sirna, monocytes, ccr, cells, pubmed, google, scholar, fig, siccr, treatment, pmc, mice, article, inflammatory, imaging, free, lychigh, silencing, monocyte, macrophages, inflammation, supplementary, reduced, delivery, disease, splenic, control, tumor, fluorescence, spleen, size, islet, recruitment, data, group, myocardial, analysis, tissue, number, immune, cancer, targeting, bone, infarct, cell, vivo, study, fmt, treated,
Topics {✒️}
c12-200/disteroylphosphatidyl choline/cholesterol/peg–dmg nanoparticle-encapsulated af647-coupled sirna glucan-receptor mediated pathway11 pan-leukocyte marker cd45 chemokine/chemokine receptor function sorted ly-6chigh monocytes hybrid pet-optical imaging pmc beta search nanoparticle-encapsulated sirna results facilitate breast-tumour metastasis nanoparticle-encapsulated sirna distributes ly-6chigh monocytes isolated splenic ly-6chigh monocytes ly-6chigh monocytes retrieved inflammatory ly-6chigh monocytes post-mi heart failure17 intra-parenchymal sirna distribution anti-inflammatory strategy focusing conventional anti-inflammatory therapy yeast-based glucan particles pancreatic islet allografts cr1 monocyte-derived cells dynamic fmt-ct imaging specific anti-inflammatory therapy sirna blood half-life efficacious systemic delivery nanoparticle-encapsulated siccr2 resulted chemokine receptor ccr2 full length blot x-ray ct technology shows promise pancreatic islet transplantation large monocyte reservoir af647-coupled sirna ccr2 receptor protein computed tomography showed cationic lipid c12-200 representative dot-plots splenic monocyte reservoir graft-dependent normoglycemia sirna targeting ccr2 ly-6chigh monocytes precise therapeutic targeting rnai-mediated mechanism pancreatic islet transplants strong inflammatory response inflammatory monocyte subset inflammatory monocyte subset license information pmcid encapsulated nucleic acids
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