
NCBI . NLM . NIH . GOV {
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Title[redir]:
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors - PMC
Description:
Hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) are routinely isolated using various markers but remain heterogeneous. Here we show that four SLAM family markers, CD150, CD48, CD229, and CD244, can distinguish HSCs ...
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Keywords {🔍}
cells, hsc, mpp, mice, doi, figure, recipients, hpc, cell, stem, hscs, bone, hematopoietic, marrow, reconstitution, pubmed, google, scholar, recipient, figures, reconstituted, donor, longterm, multilineage, scffl, progenitors, blood, myeloid, secondary, pmc, markers, potential, mpps, data, transplantation, weeks, article, expression, irradiated, population, transplanted, tiecre, leprcre, levels, free, slam, transiently, lineage, family, perivascular,
Topics {✒️}
cd150−cd48−/lowcd229−/lowcd244−lsk mpp-1 cells cd150+cd48−/lowcd229+cd244−lsk hsc-2 cells cd150−cd48−/lowcd229+cd244−lsk mpp-2 cells cd150−cd48−/lowcd229+cd244+lsk mpp-3 cells thy1lowsca-1+lineage−mac-1−cd4−c-kit+ lineage−/lowsca-1+c-kit+ resolve flt3+cd34+lsk cells flk2/flt3-positive progenitor cells selecting c150−cd48−lsk cells cd150−cd48+lsk hpc-1 cells cd150+cd48+lsk hpc-2 cells rarely-dividing myeloid-biased hscs long-term lymphohematopoietic reconstitution considered long-term reconstituted long-term multilineage reconstituted pmc beta search hematopoietic stem-cell differentiation cd150+cd48+lsk fractions long-term repopulating subset c150+cd48−lsk hscs long-term reconstituting subset cd150−cd48−/lowlsk mpps pe-conjugated anti-cd244 thy1losca-1+lineage−mac-1lowcd4low lymphoid-primed multipotent progenitors cd34+flt3+lsk population cd34+flt3+lsk populations cxcl12-cxcr4 chemokine signaling supplemental experimental procedures stem/progenitor cell population rosa26-m2-rtta streptavidin pe-texas red mixed myeloerythroid/megakaryocyte colonies functionally-distinct fractions experimental procedures mice functionally distinct subpopulations resolve distinct subpopulations vascular/perivascular scf expression figures s3b-s3d show slam family receptors supplementary materials included cd150+cd48−/lowlsk cd150−cd48−/lowlsk transient multilineage reconstitution cd34−/low hsc-2 cells lsk hematopoietic stem megakaryocyte/erythrocyte lineage cells cd150+cd48−lsk cd150−cd48−lsk cd150−cd48+lsk
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