We are analyzing https://link.springer.com/chapter/10.1007/978-1-4939-2895-8_1.

Title:
Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms | SpringerLink
Description:
The history of glucocorticoid hormone research is an excellent example of “bedside to bench” investigation. It started with two very insightful clinical observations. Thomas Addison described the syndrome of what came to be known as adrenal hormone...
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms
      pageEnd:31
      pageStart:3
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-2895-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Glucocorticoid Signaling
         isbn:
            978-1-4939-2895-8
            978-1-4939-2894-1
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Daryl K. Granner
            affiliation:
                  name:University of Iowa Carver College of Medicine
                  address:
                     name:Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Iowa Carver College of Medicine
                  address:
                     name:Department Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, USA
                     type:PostalAddress
                  type:Organization
                  name:Vanderbilt University School of Medicine
                  address:
                     name:Vanderbilt University School of Medicine, Nashville, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jen-Chywan Wang
            affiliation:
                  name:University of California Berkeley
                  address:
                     name:Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Keith R. Yamamoto
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Glucocorticoids, Gene expression, Nuclear receptors, Transcription factors, DNA elements
      description:The history of glucocorticoid hormone research is an excellent example of “bedside to bench” investigation. It started with two very insightful clinical observations. Thomas Addison described the syndrome of what came to be known as adrenal hormone insufficiency and Harvey Cushing the syndrome of glucocorticoid hormone excess. These dramatic and life-threatening conditions spawned 150 years of active research that has involved many disciplines; indeed some of the fundamental observations of molecular biology are the result of this work. We have a fundamental knowledge of how glucocorticoids regulate gene transcription, their major effect. The challenge facing current and future investigators is to discern how to use this information to make these powerful therapeutic agents safer and more effective.
      datePublished:2015
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Book:
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      isbn:
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         978-1-4939-2894-1
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      name:Springer New York
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Iowa Carver College of Medicine
      address:
         name:Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, USA
         type:PostalAddress
      name:University of Iowa Carver College of Medicine
      address:
         name:Department Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, USA
         type:PostalAddress
      name:Vanderbilt University School of Medicine
      address:
         name:Vanderbilt University School of Medicine, Nashville, USA
         type:PostalAddress
      name:University of California Berkeley
      address:
         name:Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Daryl K. Granner
      affiliation:
            name:University of Iowa Carver College of Medicine
            address:
               name:Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, USA
               type:PostalAddress
            type:Organization
            name:University of Iowa Carver College of Medicine
            address:
               name:Department Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, USA
               type:PostalAddress
            type:Organization
            name:Vanderbilt University School of Medicine
            address:
               name:Vanderbilt University School of Medicine, Nashville, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jen-Chywan Wang
      affiliation:
            name:University of California Berkeley
            address:
               name:Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, USA
               type:PostalAddress
            type:Organization
      name:Keith R. Yamamoto
      affiliation:
            name:University of California, San Francisco
            address:
               name:Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, USA
      name:Department Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, USA
      name:Vanderbilt University School of Medicine, Nashville, USA
      name:Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, USA
      name:Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, USA
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