NCBI . NLM . NIH . GOV {
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Title[redir]:
DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity - PMC
Description:
Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates target genes by associating with ...
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Keywords {🔍}
doi, fig, lever, arm, pubmed, google, scholar, dna, gbss, gbs, activity, binding, pmc, chain, genes, grγ, transcriptional, receptor, article, sequences, domain, activation, grα, sequence, activities, free, site, nlm, structure, target, gilz, complexes, grdbd, distinct, science, specific, sites, regulatory, endogenous, pal, similar, residues, biol, ncbi, search, affinities, sem, shown, revealed, data,
Topics {✒️}
org/cgi/content/full/324/5925/407/dc1 references swi/snf subunit brahma pmc beta search sequence-specific allosteric ligand nf-κb dimers gr–dna binding domain variable half site isoform-specific target genes transcription start site full-length receptor single nucleotide differences gbs motif mediated produce gene-specific full-length gr trends biochem sci conducted affinity assays supporting online material g470a reduced activation identical half sites lever arm revealed gr binding sequences dna binding proteins including dna sequence dna backbone contacts constructed luciferase reporters human gr-dbd 380 precise nucleotide sequence dna sequences serve nih grant gm08537 amino acid residues specific genomic loci nuclear hormone receptors composite omit maps composite omit map single-letter abbreviations supplementary materials included minor groove gbs reporter plasmids predominant grα isoform affect gr function united states government final edited form license information pmcid typically imperfect palindromic e219k/f220l/w234r x-ray crystallography precluded definitive attribution c-terminal helix weak hydrogen bond small environmental shifts
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