
DOI . ORG {
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Title[redir]:
Risk factors for self-reported arm lymphedema among female breast cancer survivors: a prospective cohort study | Breast Cancer Research | Full Text
Description:
Lymphedema is a potentially debilitating condition that occurs among breast cancer survivors. This study examines the incidence of self-reported lymphedema, timing of lymphedema onset, and associations between sociodemographic, clinical and lifestyle factors and lymphedema risk across racial-ethnic groups using data from a multicenter, multiethnic prospective cohort study of breast cancer survivors, the Health, Eating, Activity and Lifestyle Study. A total of 666 women diagnosed with breast cancer staged as in situ, localized or regional disease at ages 35 to 64 years were recruited through the Surveillance, Epidemiology, and End Results registries in New Mexico (non-Hispanic white and Hispanic white), Los Angeles County (black), and Western Washington (non-Hispanic white) and followed for a median of 10.2 years. We evaluated sociodemographic factors, breast cancer- and treatment-related factors, comorbidities, body mass index (BMI), hormonal factors, and lifestyle factors in relation to self-reported lymphedema by fitting Cox proportional hazards models, estimating hazard ratios (HR) and 95% confidence intervals (CI). Over the follow-up period, 190 women (29%) reported lymphedema. The median time from breast cancer diagnosis to onset of lymphedema was 10.5 months (range: 0.5 to 134.9 months). Factors independently associated with lymphedema were total/modified radical mastectomy (versus partial/less than total mastectomy; HR = 1.37, 95% CI: 1.01 to 1.85), chemotherapy (versus no chemotherapy; HR = 1.48, 95% CI: 1.09 to 2.02), no lymph nodes removed (versus ≥10 lymph nodes removed; HR = 0.17, 95% CI: 0.08 to 0.33), pre-diagnostic BMI ≥30 kg/m2 (versus BMI <25 kg/m2; HR = 1.59, 95% CI: 1.09 to 2.31), and hypertension (versus no hypertension; HR = 1.49, 95% CI: 1.06 to 2.10). After adjusting for demographics and breast cancer- and treatment-related factors, no significant difference in lymphedema risk was observed across racial/ethnic groups. Analyses stratified by race/ethnicity showed that hypertension and chemotherapy were lymphedema risk factors only for black women. Breast cancer patients who have undergone extensive surgery or extensive lymph node dissection, or who have a higher BMI should be closely monitored for detection and treatment of lymphedema. Further studies are needed to understand the roles of chemotherapy and hypertension in the development of lymphedema.
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Keywords {🔍}
lymphedema, cancer, breast, women, risk, study, pubmed, article, factors, diagnosis, google, scholar, hypertension, lymph, age, chemotherapy, bmi, assessment, years, data, black, followup, treatment, month, studies, association, survivors, incidence, model, nodes, node, prior, number, white, time, arm, health, results, surgery, versus, raceethnicity, lateonset, information, mexico, year, central, cohort, significant, analyses, patients,
Topics {✒️}
springer nature alfano & rachel ballard-barbash pre-diagnostic bmi ≥30 kg/m2 author information authors authors’ original file introduction lymphedema race/ethnicity-adjusted model based materials sharing bmc cancer measuring hormone-related symptoms authors scientific editing breast cancer-related lymphedema breast cancer-related lymphedema early-stage breast cancer lymph node removed full size image lymph node metastasis additional file 1 important intellectual content race/ethnicity-adjusted analyses original author population-based cancer registries nipple/central portion developing late-onset lymphedema upper/lower outer quadrant race/ethnicity-adjusted model late-onset lymphedema decreased privacy choices/manage cookies methods study setting late-onset lymphedema increased racial/ethnic group total/modified radical mastectomy breast cancer-related breast cancer survivors irwin ml invasive breast cancer operable breast cancer grant m01-rr-00037 considered late-onset lymphedema jane sullivan-halley submitted manuscript adjuvant epirubicin/cyclophosphamide chemotherapy beckman research institute clinical research center breast cancer staged ashley wilder smith racial/ethnic classification chemotherapy metabolite acrolein cancer treat rev
Questions {❓}
- Hayes SB, Freedman GM, Li T, Anderson PR, Ross E: Does axillary boost increase lymphedema compared with supraclavicular radiation alone after breast conservation?
- Soran A, D'Angelo G, Begovic M, Ardic F, Harlak A, Samuel Wieand H, Vogel VG, Johnson RR: Breast cancer-related lymphedema-what are the significant predictors and how they affect the severity of lymphedema?
- We then asked the following ‘yes’ or ‘no’ question: ‘Have you experienced lymphedema in your arm at any time since your breast cancer diagnosis?
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headline:Risk factors for self-reported arm lymphedema among female breast cancer survivors: a prospective cohort study
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datePublished:2014-08-22T00:00:00Z
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Sentinel Lymph Node Biopsy
Black Woman
Breast Cancer Survivor
Lymphedema
Breast Cancer Diagnosis
Cancer Research
Oncology
Surgical Oncology
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