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Title:
Risk factors associated with breast cancer-related lymphedema in the WHEL Study | Journal of Cancer Survivorship
Description:
Introduction Lymphedema is a significant health problem faced by a large percentage of breast cancer survivors. The Women’s Healthy Eating and Living (WHEL) Study has a unique dataset collected after the completion of breast cancer treatment, which allowed a focused analysis of risk factors for breast cancer-related lymphedema. Methods Participant characteristics, treatment modalities, and health behaviors were examined as potential predictors of lymphedema among breast cancer survivors with univariate analyses and multivariate logistic regression. Results Lymphedema status was assessed for 83 % of the study cohort (2,431 of the 2,917 WHEL participants). Among these respondents, 692 (28.5 %) women reported yes to either a physician’s diagnosis of lymphedema or a question on arm/hand swelling. When compared to other participants, women with lymphedema were diagnosed at a younger age, more likely to have a higher body mass index, had a larger tumor size, had more lymph nodes removed, more likely to have a mastectomy with radiation therapy, and more likely to have chemotherapy. In the final multivariate-adjusted model, body mass index greater than 25 kg/m2 (p < 0.01), the removal of 11 or more lymph nodes (p < 0.01), and breast cancer surgery plus radiation therapy (p < 0.01) showed a strong independent association with developing breast cancer-related lymphedema. Conclusions The results of this study highlight the importance of educating breast cancer survivors about the modifiable risk factors (e.g., body mass index) associated with the development of lymphedema. Implications for Cancer Survivors Breast cancer survivors at risk for lymphedema may benefit from interventions aimed at achieving or maintaining a healthy body weight.
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Keywords {🔍}
cancer, breast, article, lymphedema, google, scholar, pubmed, study, risk, factors, survivors, whel, women, health, pierce, treatment, body, oncol, content, research, natarajan, lymph, access, national, privacy, cookies, journal, womens, healthy, mass, index, cas, data, publish, search, cancerrelated, john, eating, living, arm, institute, clin, surg, node, physical, activity, information, log, survivorship, dominick,
Topics {✒️}
month download article/chapter body mass index breast cancer-related lymphedema final multivariate-adjusted model plant-based dietary pattern breast carcinoma-related lymphedema sentinel node biopsy breast cancer survivors health grants m01-rr00070 breast cancer treatment full article pdf breast cancer patients cancer survivorship aims breast cancer surgery breast cancer 5 years lymph nodes removed excised lymph nodes privacy choices/manage cookies corporeality/body image modifiable risk factors lymphedema risk factors related subjects breast cancer diagnosis check access instant access healthy body weight upper body function natl cancer inst support care cancer national cancer institute multivariate logistic regression removal ridner sh general medical sciences population-based study european economic area larger tumor size strong independent association upper extremity impairments van zee kj walton family foundation conditions privacy policy reported comorbid conditions research related oncol nurs forum breast cancer lymph nodes article journal accepting optional cookies lymphedema therapy referral
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- Breast cancer survivors suffering from lymphedema: What really do affect to corporeality/body image?
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headline:Risk factors associated with breast cancer-related lymphedema in the WHEL Study
description:Lymphedema is a significant health problem faced by a large percentage of breast cancer survivors. The Women’s Healthy Eating and Living (WHEL) Study has a unique dataset collected after the completion of breast cancer treatment, which allowed a focused analysis of risk factors for breast cancer-related lymphedema. Participant characteristics, treatment modalities, and health behaviors were examined as potential predictors of lymphedema among breast cancer survivors with univariate analyses and multivariate logistic regression. Lymphedema status was assessed for 83 % of the study cohort (2,431 of the 2,917 WHEL participants). Among these respondents, 692 (28.5 %) women reported yes to either a physician’s diagnosis of lymphedema or a question on arm/hand swelling. When compared to other participants, women with lymphedema were diagnosed at a younger age, more likely to have a higher body mass index, had a larger tumor size, had more lymph nodes removed, more likely to have a mastectomy with radiation therapy, and more likely to have chemotherapy. In the final multivariate-adjusted model, body mass index greater than 25 kg/m2 (p < 0.01), the removal of 11 or more lymph nodes (p < 0.01), and breast cancer surgery plus radiation therapy (p < 0.01) showed a strong independent association with developing breast cancer-related lymphedema. The results of this study highlight the importance of educating breast cancer survivors about the modifiable risk factors (e.g., body mass index) associated with the development of lymphedema. Breast cancer survivors at risk for lymphedema may benefit from interventions aimed at achieving or maintaining a healthy body weight.
datePublished:2012-12-05T00:00:00Z
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Lymphedema
Risk factors
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Lymph node removal
Breast cancer treatment
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Health Informatics
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Primary Care Medicine
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description:Lymphedema is a significant health problem faced by a large percentage of breast cancer survivors. The Women’s Healthy Eating and Living (WHEL) Study has a unique dataset collected after the completion of breast cancer treatment, which allowed a focused analysis of risk factors for breast cancer-related lymphedema. Participant characteristics, treatment modalities, and health behaviors were examined as potential predictors of lymphedema among breast cancer survivors with univariate analyses and multivariate logistic regression. Lymphedema status was assessed for 83 % of the study cohort (2,431 of the 2,917 WHEL participants). Among these respondents, 692 (28.5 %) women reported yes to either a physician’s diagnosis of lymphedema or a question on arm/hand swelling. When compared to other participants, women with lymphedema were diagnosed at a younger age, more likely to have a higher body mass index, had a larger tumor size, had more lymph nodes removed, more likely to have a mastectomy with radiation therapy, and more likely to have chemotherapy. In the final multivariate-adjusted model, body mass index greater than 25 kg/m2 (p < 0.01), the removal of 11 or more lymph nodes (p < 0.01), and breast cancer surgery plus radiation therapy (p < 0.01) showed a strong independent association with developing breast cancer-related lymphedema. The results of this study highlight the importance of educating breast cancer survivors about the modifiable risk factors (e.g., body mass index) associated with the development of lymphedema. Breast cancer survivors at risk for lymphedema may benefit from interventions aimed at achieving or maintaining a healthy body weight.
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Lymphedema
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Lymph node removal
Breast cancer treatment
Public Health
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Health Promotion and Disease Prevention
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Quality of Life Research
Primary Care Medicine
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