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Title:
Comorbidities, therapy, and newly diagnosed conditions for women with early stage breast cancer | Journal of Cancer Survivorship
Description:
Purpose To describe comorbidities in breast cancer patients at diagnosis and examine factors associated with self-reported comorbidities 30 months post-diagnosis. Methods Nine hundred forty one of 1,171 women had a medical record abstract and a follow-up survey in the Health, Eating, Activity and Lifestyle Study. Results We compared our breast cancer cohort to a contemporaneous nationally-representative sample of age, race/ethnicity and education matched women without cancer (nβ=β865). Breast cancer patients did not have substantially more comorbidities than women without breast cancer. Women with a hospital record of congestive heart failure significantly less often received chemotherapy or radiation following breast conserving surgery. In multivariate analysis, women who received chemotherapy alone (ORβ=β3.2; 95% CI: 1.5β6.8), chemotherapy plus radiation (ORβ=β1.9; 95% CI: 1.02β3.7) or radiation plus tamoxifen (ORβ=β1.9; 95% CI: 1.1β3.2) were significantly more likely to report at least one new comorbid condition following breast cancer diagnosis than women who received no chemotherapy, tamoxifen or radiation. Overall, women who received adjuvant therapy were more likely to have new comorbidities. Conclusions Comorbidities were not substantially different in breast cancer patients than the non-cancer matched controls. Future research should focus on efforts to minimize comorbidities related to chemotherapy and other combination therapy.
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Keywords {π}
cancer, breast, article, google, scholar, women, pubmed, therapy, cas, chemotherapy, comorbidities, patients, research, harlan, comorbidity, usa, journal, age, radiation, privacy, cookies, content, information, early, received, med, older, data, publish, search, conditions, klabunde, study, adjuvant, related, access, survival, diabetes, log, diagnosed, stage, linda, ambs, mctiernan, ballardbarbash, cohort, tamoxifen, discover, care, assoc,
Topics {βοΈ}
gov/nchs/products/elec_prods/subject/nhanes3 american cancer society month download article/chapter contemporaneous nationally-representative sample combination therapy breast cancer research breast cancer cohort n01-pc-35138 rights adjuvant systemic therapy breast cancer patients early breast cancer breast cancer survival full article pdf privacy choices/manage cookies received adjuvant therapy breast cancer diagnosis breast cancer treatment primary breast cancer cancer survivorship aims national cancer institute meta-analysis article 20 leslie bernstein cancer matched controls natl cancer inst conditions privacy policy newly diagnosed conditions european economic area medical record abstract radiation therapy minimize comorbidities related breast conserving surgery nursesβ health study classifying prognostic comorbidity accepting optional cookies related subjects anne mctiernan ann intern med breast cancer check access instant access journal finder publish education matched women author correspondence n01-pc-35142 article journal article log article harlan future research tamoxifen therapy article cite
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- Do patients consistently report comorbid conditions over time?
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headline:Comorbidities, therapy, and newly diagnosed conditions for women with early stage breast cancer
description:To describe comorbidities in breast cancer patients at diagnosis and examine factors associated with self-reported comorbidities 30Β months post-diagnosis. Nine hundred forty one of 1,171 women had a medical record abstract and a follow-up survey in the Health, Eating, Activity and Lifestyle Study. We compared our breast cancer cohort to a contemporaneous nationally-representative sample of age, race/ethnicity and education matched women without cancer (nβ=β865). Breast cancer patients did not have substantially more comorbidities than women without breast cancer. Women with a hospital record of congestive heart failure significantly less often received chemotherapy or radiation following breast conserving surgery. In multivariate analysis, women who received chemotherapy alone (ORβ=β3.2; 95% CI: 1.5β6.8), chemotherapy plus radiation (ORβ=β1.9; 95% CI: 1.02β3.7) or radiation plus tamoxifen (ORβ=β1.9; 95% CI: 1.1β3.2) were significantly more likely to report at least one new comorbid condition following breast cancer diagnosis than women who received no chemotherapy, tamoxifen or radiation. Overall, women who received adjuvant therapy were more likely to have new comorbidities. Comorbidities were not substantially different in breast cancer patients than the non-cancer matched controls. Future research should focus on efforts to minimize comorbidities related to chemotherapy and other combination therapy.
datePublished:2009-05-13T00:00:00Z
dateModified:2009-05-13T00:00:00Z
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Therapy
Comorbidity
Healthcare
Disparities
Heart disease
Hypertension
Diabetes
Public Health
Oncology
Health Promotion and Disease Prevention
Health Informatics
Quality of Life Research
Primary Care Medicine
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headline:Comorbidities, therapy, and newly diagnosed conditions for women with early stage breast cancer
description:To describe comorbidities in breast cancer patients at diagnosis and examine factors associated with self-reported comorbidities 30Β months post-diagnosis. Nine hundred forty one of 1,171 women had a medical record abstract and a follow-up survey in the Health, Eating, Activity and Lifestyle Study. We compared our breast cancer cohort to a contemporaneous nationally-representative sample of age, race/ethnicity and education matched women without cancer (nβ=β865). Breast cancer patients did not have substantially more comorbidities than women without breast cancer. Women with a hospital record of congestive heart failure significantly less often received chemotherapy or radiation following breast conserving surgery. In multivariate analysis, women who received chemotherapy alone (ORβ=β3.2; 95% CI: 1.5β6.8), chemotherapy plus radiation (ORβ=β1.9; 95% CI: 1.02β3.7) or radiation plus tamoxifen (ORβ=β1.9; 95% CI: 1.1β3.2) were significantly more likely to report at least one new comorbid condition following breast cancer diagnosis than women who received no chemotherapy, tamoxifen or radiation. Overall, women who received adjuvant therapy were more likely to have new comorbidities. Comorbidities were not substantially different in breast cancer patients than the non-cancer matched controls. Future research should focus on efforts to minimize comorbidities related to chemotherapy and other combination therapy.
datePublished:2009-05-13T00:00:00Z
dateModified:2009-05-13T00:00:00Z
pageStart:89
pageEnd:98
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Therapy
Comorbidity
Healthcare
Disparities
Heart disease
Hypertension
Diabetes
Public Health
Oncology
Health Promotion and Disease Prevention
Health Informatics
Quality of Life Research
Primary Care Medicine
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