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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers

We began analyzing https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06167-1, but it redirected us to https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06167-1. The analysis below is for the second page.

Title[redir]:
Role of CD4+ T cells in cancer immunity: a single-cell sequencing exploration of tumor microenvironment | Journal of Translational Medicine | Full Text
Description:
Recent oncological research has intensely focused on the tumor immune microenvironment (TME), particularly the functions of CD4 + T lymphocytes. CD4+ T lymphocytes have been implicated in antigen presentation, cytokine release, and cytotoxicity, suggesting their contribution to the dynamics of the TME. Furthermore, the application of single-cell sequencing has yielded profound insights into the phenotypic diversity and functional specificity of CD4+ T cells in the TME. In this review, we discuss the current findings from single-cell analyses, emphasizing the heterogeneity of CD4+ T cell subsets and their implications in tumor immunology. In addition, we review the critical signaling pathways and molecular networks underpinning CD4+ T cell activities, thereby offering novel perspectives on therapeutic targets and strategies for cancer treatment and prognosis.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 91,155,781 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We're unsure if the website is profiting.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

cells, pubmed, cell, singlecell, cancer, article, tumor, google, scholar, sequencing, cas, immune, central, tregs, immunotherapy, tme, study, zhang, patients, cytotoxic, expression, studies, wang, genes, microenvironment, immunol, regulatory, liu, demonstrated, carcinoma, response, spatial, tumors, antitumor, icb, analysis, scrnaseq, differentiation, data, research, population, treg, act, immunity, heterogeneity, nat, function, functions, researchers, human,

Topics {✒️}

anti-pd-l1 + anti-ctla4 therapy high-dimensional single-cell transcriptomics tgf-β downregulating klrb1/cd161 class i-restricted cd8+ pd-l1-independent mechanisms control anti-fungal host defenses predicts anti-pd-l1 response th1-secreted ifn-γ induces mhc class ii-restricted single-cell sequencing reveals t-bet independently control single-nucleus rna sequencing smart-seq2 single-cell sequencing anti-pd-l1 monotherapy single-cell transcriptomics reveals single-cell analysis reveals promote epithelial–mesenchymal transition single-cell rna sequencing single-cell rna transcriptome exert anti-tumor effects heterogeneous tumor-immune microenvironments mhc-ii dependent manner single-cell sequencing exploration appling single-cell sequencing single-cell sequencing technology single-cell sequencing workflow promoting epithelial-mesenchymal transition tumor-draining lymph nodes single-cell transcriptomics identifies possess anti-tumor properties single-cell rna-seq tcga-luad dataset demonstrated anti-tumor immune effects macrophage gsk3β-deficiency inhibits mhc-ii signature correlates membrane-bound tgf-β1 single-cell sequencing promotes anti-ctla4 icb therapy single-cell sequencing technologies preventing single-cell precision exerting anti-tumor effects excellent anti-tumor effects single-cell transcriptome analysis multi-omics approach large-scale tissue analysis tumor-infiltrating human cd4 + regulatory cxcr3+ccr4−ccr6+cd4+ cxcr3−ccr4−ccr6+cd4+ bulk rna-seq data single-cell sequencing studies

Questions {❓}

  • Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Role of CD4+ T cells in cancer immunity: a single-cell sequencing exploration of tumor microenvironment
         description:Recent oncological research has intensely focused on the tumor immune microenvironment (TME), particularly the functions of CD4 + T lymphocytes. CD4+ T lymphocytes have been implicated in antigen presentation, cytokine release, and cytotoxicity, suggesting their contribution to the dynamics of the TME. Furthermore, the application of single-cell sequencing has yielded profound insights into the phenotypic diversity and functional specificity of CD4+ T cells in the TME. In this review, we discuss the current findings from single-cell analyses, emphasizing the heterogeneity of CD4+ T cell subsets and their implications in tumor immunology. In addition, we review the critical signaling pathways and molecular networks underpinning CD4+ T cell activities, thereby offering novel perspectives on therapeutic targets and strategies for cancer treatment and prognosis.
         datePublished:2025-02-14T00:00:00Z
         dateModified:2025-02-14T00:00:00Z
         pageStart:1
         pageEnd:17
         license:http://creativecommons.org/licenses/by-nc-nd/4.0/
         sameAs:https://doi.org/10.1186/s12967-025-06167-1
         keywords:
            Single-cell sequencing
            CD4+ T cells
            Tumor microenvironment
            Immunotherapy
            Biomedicine
            general
            Medicine/Public Health
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                        type:PostalAddress
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                     address:
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                        type:PostalAddress
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      headline:Role of CD4+ T cells in cancer immunity: a single-cell sequencing exploration of tumor microenvironment
      description:Recent oncological research has intensely focused on the tumor immune microenvironment (TME), particularly the functions of CD4 + T lymphocytes. CD4+ T lymphocytes have been implicated in antigen presentation, cytokine release, and cytotoxicity, suggesting their contribution to the dynamics of the TME. Furthermore, the application of single-cell sequencing has yielded profound insights into the phenotypic diversity and functional specificity of CD4+ T cells in the TME. In this review, we discuss the current findings from single-cell analyses, emphasizing the heterogeneity of CD4+ T cell subsets and their implications in tumor immunology. In addition, we review the critical signaling pathways and molecular networks underpinning CD4+ T cell activities, thereby offering novel perspectives on therapeutic targets and strategies for cancer treatment and prognosis.
      datePublished:2025-02-14T00:00:00Z
      dateModified:2025-02-14T00:00:00Z
      pageStart:1
      pageEnd:17
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         Single-cell sequencing
         CD4+ T cells
         Tumor microenvironment
         Immunotherapy
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06167-1/MediaObjects/12967_2025_6167_Fig2_HTML.png
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                  name:Renmin Hospital of Wuhan University
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                     type:PostalAddress
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                     name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
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            name:Yuanyuan Wang
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                     type:PostalAddress
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            name:Fuxin Wang
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                  name:Renmin Hospital of Wuhan University
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                     name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
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                  name:The Affiliated Cancer Hospital of Gannan Medical University
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                     type:PostalAddress
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                  address:
                     name:Department of Radiation Oncology, Peking University First Hospital, Beijing, China
                     type:PostalAddress
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                     name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
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         name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
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         name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
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         name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
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         name:Department of Radiation Oncology, Peking University First Hospital, Beijing, China
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      name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
      name:Department of Radiation Oncology, The Affiliated Cancer Hospital of Gannan Medical University, Jiangxi, China
      name:Department of Radiation Oncology, Peking University First Hospital, Beijing, China
      name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China

Social Networks {👍}(2)

External Links {🔗}(648)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com
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