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Keywords {🔍}

cells, doi, foxp, treg, pubmed, google, scholar, cell, expression, pmc, regulatory, article, free, tregspecific, autoimmune, gene, immunol, transcription, function, development, genes, diseases, tconv, dna, differentiation, ntreg, regions, epigenetic, ttreg, nature, factor, ctla, mutations, immune, tregtype, stable, control, nat, stimulation, tcr, epigenome, hypomethylation, itreg, factors, activated, histone, binding, functionally, induction, ses,

Topics {✒️}

largely include treg-drs forkhead/winged-helix protein t-cell subpopulation specialized transcription factor t-bet deposited rna-seq data treg-specific dna hypomethylation treg-specific super-enhancers treg-type dna hypomethylation super-enhancers delineate disease treg-specific dna demethylation lineage-specific dna methylation mediator establish super-enhancers lack treg-type epigenomic vitro t-cell receptor repression-related histone modification satb1-dependent super-enhancer establishment anti-cd3/cd28 antibodies genome-wide association study t-cell deficient mice treg-specific histone modifications treg-type histone modifications naïve treg-specific drs treg-specific cpg hypomethylation treg-related gene expression graft-versus-host disease activation-related histone modifications pmc beta search detectable treg-specific epigenetic antigen-specific effector/memory treg-specific gene expression treg-type gene expression activated treg-specific drs immature cd4 single-positive pre-existent enhancer landscape tgf-β-induced itreg cells conventional t-cell subpopulations treg-specific epigenome formation treg-specific se activation foxp3-independent cell commitment antigen-stimulated effector/memory establishing treg-specific ses treg-type epigenome formation activation-induced drs common monogenic autoimmune/inflammatory diseases autoimmune-suppressing treg cells runx1-cbfbeta transcription complex foxp3 transcription-factor-dependent chimeric antigen receptor foxp3-deficient treg cells foxp3-expressing treg cells

Questions {❓}

• Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
• How can Treg-type epigenome be installed in iTreg cells?
• Is FOXP3 the master control gene for Treg development and function?
• Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
• With FoxP3-independency of Treg-specific epigenetic changes, how do FoxP3 and the Treg-type epigenome, separately or coordinately, contribute to Treg-type gene expression?

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