
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma - PMC
Description:
The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding of this tumor-specific ecosystem is necessary to enhance cancer diagnosis, therapeutics, and ...
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Keywords {🔍}
cells, cell, npc, doi, fig, data, microenvironment, patients, subpopulations, analysis, pubmed, google, scholar, singlecell, exhausted, genes, patient, sequencing, supplementary, pmc, immune, article, functional, expression, free, stromal, survival, myeloid, samples, nasopharyngeal, tme, cancer, gene, based, rna, abundance, independent, tregs, values, found, nonmalignant, subtypes, naïve, scores, major, nlh, source, carcinoma, tumor, distinct,
Topics {✒️}
nuclear factor kappa-light-chain-enhancer multi-subunit ligand-receptor complexes formalin-fixed paraffin-embedded tissues code availability author contributions competing interests specific ligand-receptor connection bulk rna-sequencing cohorts worse progression-free survival35 interacting ligand-receptor pair stimulatory molecules-encoding genes supplementary tables s1–s3 single-cell sequencing technique single-cell transcriptomics data single-cell mrna quantification compute cell-cell communication inferring cell-cell communication pmc beta search activate anti-tumor immunity data availability statements data availability statement cell–cell communication network 5 mg/ml collagenase iv selected ligand-receptor interactions hong kong-shenzhen hospital theme-based research scheme single-cell sequencing data progression-free survival based antigen-specific cytotoxic response8 introduction npc store-operated calcium channels low t-immune score single-cell data showed alpha-sma-positive fibroblasts small-cell lung carcinoma gov/geo/query/acc high t-immune score augment tlr-mediated activation tertiary lymphoid structures maximum clone/sum count bulk rna sequencing conventional m1/m2 classification reveal npc-specific features sdf-1-positive tumor cells graph-based clustering approach recent single-cell studies calcium channel-dependent process epstein–barr virus low t-immune scores nlh-single-cell-analysis
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