Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://www.nature.com/articles/s41598-021-89827-8, but it redirected us to https://www.nature.com/articles/s41598-021-89827-8. The analysis below is for the second page.

Title[redir]:
Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies | Scientific Reports
Description:
Rosiglitazone is an effective insulin-sensitizer, however associated with bone loss mainly due to increased bone resorption and bone marrow adiposity. We investigated the effect of the co-administration of fish oil rich in omega-3 fatty acids (FAs) on rosiglitazone-induced bone loss in C57BL/6 mice and the mechanisms underlying potential preventive effect. Mice fed the iso-caloric diet supplemented with fish oil exhibited significantly higher levels of bone density in different regions compared to the other groups. In the same cohort of mice, reduced activity of COX-2, enhanced activity of alkaline phosphatase, lower levels of cathepsin k, PPAR-γ, and pro-inflammatory cytokines, and a higher level of anti-inflammatory cytokines were observed. Moreover, fish oil restored rosiglitazone-induced down-regulation of osteoblast differentiation and up-regulation of adipocyte differentiation in C3H10T1/2 cells and inhibited the up-regulation of osteoclast differentiation of RANKL-treated RAW264.7 cells. We finally tested our hypothesis on human Mesenchymal Stromal Cells differentiated to osteocytes and adipocytes confirming the beneficial effect of docosahexaenoic acid (DHA) omega-3 FA during treatment with rosiglitazone, through the down-regulation of adipogenic genes, such as adipsin and FABP4 along the PPARγ/FABP4 axis, and reducing the capability of osteocytes to switch toward adipogenesis. Fish oil may prevent rosiglitazone-induced bone loss by inhibiting inflammation, osteoclastogenesis, and adipogenesis and by enhancing osteogenesis in the bone microenvironment.

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

cells, bone, rsg, article, google, scholar, mice, cas, pubmed, differentiation, activity, omega, effect, dha, cell, alp, fatty, loss, acid, fas, cht, aging, usa, epa, cbl, increased, acids, osteoclastogenesis, oil, adipogenesis, diabetes, bmd, fig, resorption, diet, study, insulin, significantly, compared, stromal, rsgmediated, expression, culture, rosiglitazone, pparγ, raw, human, effects, protein, osteoclast,

Topics {✒️}

nature portfolio privacy policy real-time quantitative rt-pcr editing nature 386 nature advertising dual-energy x-ray absorptiometry qatar national library real-time rt-pcr tissue development open-label trial peroxisome proliferator-activated receptors ovariectomy-induced bone loss reprints high-fat diet-induced obesity autoimmune lupus-prone mice natural anti-inflammatory compounds22 japan tartrate-resistant acid phosphatase tumor necrosis factor-α rosiglitazone-induced bone loss rneasy mini kits research author information authors 24 h-lps-treated bm cells runt-related transcription factor potent a1c-lowering properties fatty acid-binding protein attenuate rsg-mediated stimulation pro-osteoclastogenic nf-κb rsg-mediated bone loss rsg-treated mice exhibited standard glucose-lowering drugs7 multiple comparison tests multiple-comparison tests inhibiting tnf-alpha production unique insulin-sensitizing capacity2 clinical-grade fat digestion rsg-mediated bone resorption revert rsg-induced adipogenesis conjugated linoleic acid tnf‐α‐induced osteoclastogenesis fish oil rich parathyroid hormone-related protein house-keeping gene gapdh l-ascorbic acid 2-phosphate rsg-mediated bmd loss original author alleviate rsg-mediated increase

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies
         description:Rosiglitazone is an effective insulin-sensitizer, however associated with bone loss mainly due to increased bone resorption and bone marrow adiposity. We investigated the effect of the co-administration of fish oil rich in omega-3 fatty acids (FAs) on rosiglitazone-induced bone loss in C57BL/6 mice and the mechanisms underlying potential preventive effect. Mice fed the iso-caloric diet supplemented with fish oil exhibited significantly higher levels of bone density in different regions compared to the other groups. In the same cohort of mice, reduced activity of COX-2, enhanced activity of alkaline phosphatase, lower levels of cathepsin k, PPAR-γ, and pro-inflammatory cytokines, and a higher level of anti-inflammatory cytokines were observed. Moreover, fish oil restored rosiglitazone-induced down-regulation of osteoblast differentiation and up-regulation of adipocyte differentiation in C3H10T1/2 cells and inhibited the up-regulation of osteoclast differentiation of RANKL-treated RAW264.7 cells. We finally tested our hypothesis on human Mesenchymal Stromal Cells differentiated to osteocytes and adipocytes confirming the beneficial effect of docosahexaenoic acid (DHA) omega-3 FA during treatment with rosiglitazone, through the down-regulation of adipogenic genes, such as adipsin and FABP4 along the PPARγ/FABP4 axis, and reducing the capability of osteocytes to switch toward adipogenesis. Fish oil may prevent rosiglitazone-induced bone loss by inhibiting inflammation, osteoclastogenesis, and adipogenesis and by enhancing osteogenesis in the bone microenvironment.
         datePublished:2021-05-14T00:00:00Z
         dateModified:2021-05-14T00:00:00Z
         pageStart:1
         pageEnd:18
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/s41598-021-89827-8
         keywords:
            Drug safety
            Endocrine system and metabolic diseases
            Mesenchymal stem cells
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig6_HTML.png
         isPartOf:
            name:Scientific Reports
            issn:
               2045-2322
            volumeNumber:11
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Chiara Cugno
               affiliation:
                     name:Sidra Medicine
                     address:
                        name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dhanya Kizhakayil
               affiliation:
                     name:Sidra Medicine
                     address:
                        name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rita Calzone
               affiliation:
                     name:Sidra Medicine
                     address:
                        name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shaikh Mizanoor Rahman
               affiliation:
                     name:University of Nizwa
                     address:
                        name:Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ganesh V. Halade
               affiliation:
                     name:The University of South Florida Health
                     address:
                        name:Division of Cardiovascular Sciences, The University of South Florida Health, Tampa, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Md M. Rahman
               affiliation:
                     name:Qatar University
                     address:
                        name:Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies
      description:Rosiglitazone is an effective insulin-sensitizer, however associated with bone loss mainly due to increased bone resorption and bone marrow adiposity. We investigated the effect of the co-administration of fish oil rich in omega-3 fatty acids (FAs) on rosiglitazone-induced bone loss in C57BL/6 mice and the mechanisms underlying potential preventive effect. Mice fed the iso-caloric diet supplemented with fish oil exhibited significantly higher levels of bone density in different regions compared to the other groups. In the same cohort of mice, reduced activity of COX-2, enhanced activity of alkaline phosphatase, lower levels of cathepsin k, PPAR-γ, and pro-inflammatory cytokines, and a higher level of anti-inflammatory cytokines were observed. Moreover, fish oil restored rosiglitazone-induced down-regulation of osteoblast differentiation and up-regulation of adipocyte differentiation in C3H10T1/2 cells and inhibited the up-regulation of osteoclast differentiation of RANKL-treated RAW264.7 cells. We finally tested our hypothesis on human Mesenchymal Stromal Cells differentiated to osteocytes and adipocytes confirming the beneficial effect of docosahexaenoic acid (DHA) omega-3 FA during treatment with rosiglitazone, through the down-regulation of adipogenic genes, such as adipsin and FABP4 along the PPARγ/FABP4 axis, and reducing the capability of osteocytes to switch toward adipogenesis. Fish oil may prevent rosiglitazone-induced bone loss by inhibiting inflammation, osteoclastogenesis, and adipogenesis and by enhancing osteogenesis in the bone microenvironment.
      datePublished:2021-05-14T00:00:00Z
      dateModified:2021-05-14T00:00:00Z
      pageStart:1
      pageEnd:18
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41598-021-89827-8
      keywords:
         Drug safety
         Endocrine system and metabolic diseases
         Mesenchymal stem cells
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-021-89827-8/MediaObjects/41598_2021_89827_Fig6_HTML.png
      isPartOf:
         name:Scientific Reports
         issn:
            2045-2322
         volumeNumber:11
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Chiara Cugno
            affiliation:
                  name:Sidra Medicine
                  address:
                     name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dhanya Kizhakayil
            affiliation:
                  name:Sidra Medicine
                  address:
                     name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rita Calzone
            affiliation:
                  name:Sidra Medicine
                  address:
                     name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shaikh Mizanoor Rahman
            affiliation:
                  name:University of Nizwa
                  address:
                     name:Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ganesh V. Halade
            affiliation:
                  name:The University of South Florida Health
                  address:
                     name:Division of Cardiovascular Sciences, The University of South Florida Health, Tampa, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Md M. Rahman
            affiliation:
                  name:Qatar University
                  address:
                     name:Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Scientific Reports
      issn:
         2045-2322
      volumeNumber:11
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Sidra Medicine
      address:
         name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
         type:PostalAddress
      name:Sidra Medicine
      address:
         name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
         type:PostalAddress
      name:Sidra Medicine
      address:
         name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
         type:PostalAddress
      name:University of Nizwa
      address:
         name:Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
         type:PostalAddress
      name:The University of South Florida Health
      address:
         name:Division of Cardiovascular Sciences, The University of South Florida Health, Tampa, USA
         type:PostalAddress
      name:Qatar University
      address:
         name:Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Chiara Cugno
      affiliation:
            name:Sidra Medicine
            address:
               name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
               type:PostalAddress
            type:Organization
      name:Dhanya Kizhakayil
      affiliation:
            name:Sidra Medicine
            address:
               name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
               type:PostalAddress
            type:Organization
      name:Rita Calzone
      affiliation:
            name:Sidra Medicine
            address:
               name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
               type:PostalAddress
            type:Organization
      name:Shaikh Mizanoor Rahman
      affiliation:
            name:University of Nizwa
            address:
               name:Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
               type:PostalAddress
            type:Organization
      name:Ganesh V. Halade
      affiliation:
            name:The University of South Florida Health
            address:
               name:Division of Cardiovascular Sciences, The University of South Florida Health, Tampa, USA
               type:PostalAddress
            type:Organization
      name:Md M. Rahman
      affiliation:
            name:Qatar University
            address:
               name:Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
      name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
      name:Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar
      name:Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
      name:Division of Cardiovascular Sciences, The University of South Florida Health, Tampa, USA
      name:Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar

Social Networks {👍}(2)

External Links {🔗}(516)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

5.75s.