We are analyzing https://link.springer.com/article/10.1007/s00125-009-1305-z.

Title:
n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet | Diabetologia
Description:
Aims/hypothesis Fatty acids of marine origin, i.e. docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) act as hypolipidaemics, but they do not improve glycaemic control in obese and diabetic patients. Thiazolidinediones like rosiglitazone are specific activators of peroxisome proliferator-activated receptor γ, which improve whole-body insulin sensitivity. We hypothesised that a combined treatment with a DHA and EPA concentrate (DHA/EPA) and rosiglitazone would correct, by complementary additive mechanisms, impairments of lipid and glucose homeostasis in obesity. Methods Male C57BL/6 mice were fed a corn oil-based high-fat diet. The effects of DHA/EPA (replacing 15% dietary lipids), rosiglitazone (10 mg/kg diet) or a combination of both on body weight, adiposity, metabolic markers and adiponectin in plasma, as well as on liver and muscle gene expression and metabolism were analysed. Euglycaemic–hyperinsulinaemic clamps were used to characterise the changes in insulin sensitivity. The effects of the treatments were also analysed in dietary obese mice with impaired glucose tolerance (IGT). Results DHA/EPA and rosiglitazone exerted additive effects in prevention of obesity, adipocyte hypertrophy, low-grade adipose tissue inflammation, dyslipidaemia and insulin resistance, while inducing adiponectin, suppressing hepatic lipogenesis and decreasing muscle ceramide concentration. The improvement in glucose tolerance reflected a synergistic stimulatory effect of the combined treatment on muscle glycogen synthesis and its sensitivity to insulin. The combination treatment also reversed dietary obesity, dyslipidaemia and IGT. Conclusions/interpretation DHA/EPA and rosiglitazone can be used as complementary therapies to counteract dyslipidaemia and insulin resistance. The combination treatment may reduce dose requirements and hence the incidence of adverse side effects of thiazolidinedione therapy.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

mice, rosiglitazone, google, scholar, insulin, diet, treatment, pubmed, muscle, glucose, article, chf, effects, chfftzd, effect, chftzd, chff, fig, fatty, treatments, weeks, dhaepa, combination, body, weight, adiponectin, tissue, lcpufa, adipose, table, sensitivity, synthesis, lipid, liver, hepatic, difference, levels, content, acid, dietary, acids, glycogen, highfat, obesity, plasma, esm, increased, diabetes, white, igt,

Topics {✒️}

quantitative real-time rt-pcr peroxisome proliferator-activated receptor-gamma high-fat diet-induced hyperglycemia a-zip/f-1 fatless mice amp-activated protein kinase high-fat diet-induced disorders peroxisome proliferator-activated receptor ppar-gamma-induced triglyceride lowering peroxisome proliferator-activated receptors hormone-sensitive lipase deficiency krebs–ringer bicarbonate buffer toxic fatty acid-derivatives overweight pre-menopausal women omega-3-derived local mediators stearoyl-coa desaturase activity hepatic vldl-triacylglycerol production male c57bl/6n mice ppar-alpha-dependent manner n-3 fatty acids polyunsaturated fatty acids reduces obesity-related inflammation hepatic vldl-triacylglycerol synthesis tissue-specific postprandial clearance synthetic ppar-α agonists subsequent 8-week-long treatment protecting insulin signalling fish oil triglycerides dietary fish oil preserve akt/pkb phosphorylation fish-oil supplementation hepatic gene expression conclusions/interpretation dha/epa omega-3 fatty acids insulin-mediated glucose uptake esterified fatty acids electronic supplementary material fatty acid oxidation fatty acid synthase allowed free access liver vldl-triacylglycerol synthesis high-fat diet fatty acid composition metabolism research group chow diet-fed mice insulin-stimulated glycogen synthesis hepatic nuclear factor-4 privacy choices/manage cookies high-fat feeding overweight hypertensive subjects hepatic glucose production

Questions {❓}

Is adipocyte size associated with inflammation in adults?
Yang X, Smith U (2007) Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?

Schema {🗺️}

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      name:L. Kazdova
      affiliation:
            name:Institute of Clinical and Experimental Medicine
            address:
               name:Institute of Clinical and Experimental Medicine, Prague, Czech Republic
               type:PostalAddress
            type:Organization
      name:N. Ogston
      affiliation:
            name:University College London
            address:
               name:Adipokines and Metabolism Research Group, Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
               type:PostalAddress
            type:Organization
      name:M. Baranowski
      affiliation:
            name:Medical University of Bialystok
            address:
               name:Department of Physiology, Medical University of Bialystok, Bialystok, Poland
               type:PostalAddress
            type:Organization
      name:J. Gorski
      affiliation:
            name:Medical University of Bialystok
            address:
               name:Department of Physiology, Medical University of Bialystok, Bialystok, Poland
               type:PostalAddress
            type:Organization
      name:P. Janovska
      affiliation:
            name:Institute of Physiology of the Academy of Sciences of the Czech Republic
            address:
               name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
               type:PostalAddress
            type:Organization
      name:V. Kus
      affiliation:
            name:Institute of Physiology of the Academy of Sciences of the Czech Republic
            address:
               name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
               type:PostalAddress
            type:Organization
      name:J. Polak
      affiliation:
            name:Charles University
            address:
               name:Department of Sport Medicine, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
               type:PostalAddress
            type:Organization
      name:V. Mohamed-Ali
      affiliation:
            name:University College London
            address:
               name:Adipokines and Metabolism Research Group, Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
               type:PostalAddress
            type:Organization
      name:R. Burcelin
      affiliation:
            name:INSERM U858 Institute of Molecular Medicine, IFR31, Rangueil Hospital
            address:
               name:INSERM U858 Institute of Molecular Medicine, IFR31, Rangueil Hospital, Toulouse, France
               type:PostalAddress
            type:Organization
      name:S. Cinti
      affiliation:
            name:University of Ancona
            address:
               name:Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
               type:PostalAddress
            type:Organization
      name:M. Bryhn
      affiliation:
            name:Silentia AS
            address:
               name:Silentia AS, Svelvik, Norway
               type:PostalAddress
            type:Organization
      name:J. Kopecky
      affiliation:
            name:Institute of Physiology of the Academy of Sciences of the Czech Republic
            address:
               name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Institute of Clinical and Experimental Medicine, Prague, Czech Republic
      name:Adipokines and Metabolism Research Group, Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
      name:Department of Physiology, Medical University of Bialystok, Bialystok, Poland
      name:Department of Physiology, Medical University of Bialystok, Bialystok, Poland
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
      name:Department of Sport Medicine, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
      name:Adipokines and Metabolism Research Group, Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
      name:INSERM U858 Institute of Molecular Medicine, IFR31, Rangueil Hospital, Toulouse, France
      name:Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
      name:Silentia AS, Svelvik, Norway
      name:Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic

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