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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://www.nature.com/articles/s41580-019-0199-y, but it redirected us to https://www.nature.com/articles/s41580-019-0199-y. The analysis below is for the second page.

Title[redir]:
mTOR at the nexus of nutrition, growth, ageing and disease | Nature Reviews Molecular Cell Biology
Description:
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. The mTOR pathway integrates diverse environmental cues to control biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing, and is thus a promising target for pharmacological intervention.

Matching Content Categories {📚}

  • Education
  • Business & Finance
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

check SE Ranking
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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, cell, mtorc, mtor, biol, nature, complex, signaling, rapamycin, mol, pathway, science, kinase, autophagy, protein, activation, regulation, phosphorylation, nat, amino, growth, cancer, regulates, sabatini, target, mammalian, chem, study, tsc, sci, acid, activity, tor, tumor, mice, cells, genes, function, signalling, synthesis, control, disease, factor, inhibition, dev,

Topics {✒️}

activating α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid permissions reprints privacy policy cytosol-open state nature portfolio journals scientific advisory board editing middle-aged mice ulk1–atg13–fip200 complex required advertising nature portfolio integrative cancer research mtor/s6k/4e-bp signaling yy1–pgc-1α transcriptional complex social media national library medical research brain-derived neurotrophic factor mediate cell-type-specific repression g1-arresting rapamycin–receptor complex biomedical research amino-acid-sensing pathway upstream amino-acid-replete conditions lipid-activated transcription factor foxo1–pgc-1α interaction discussed article content ubp3p/bre5p ubiquitin protease dox-loaded sio2 nanoparticles tumor-promoting phorbol esters atp-competitive catalytic inhibitor carboxy-terminal activation domain birt–hogg–dube syndrome golgi–lysosome contact site gtpase-activating protein complex elegans larval development female c57bl/6j mice author information authors amino acid-dependent activation pi3k/akt/mtor axis immuno-electron microscopy study rag gtpase-dependent manner nutrient-dependent mtorc1 association feedback-dependent biphasic regulation insulin-regulated hepatic gluconeogenesis mtor-regulated phosphoproteome reveals rapid antidepressant effects igf-1–akt–mtor pathways eif-4e bp1 phosphorylation phosphoinositide 3-kinase/akt pathway tumor suppressor complex

Questions {❓}

  • Rapamycin and Alzheimer’s disease: time for a clinical trial?

Schema {🗺️}

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         description:The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. The mTOR pathway integrates diverse environmental cues to control biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing, and is thus a promising target for pharmacological intervention.
         datePublished:2020-01-14T00:00:00Z
         dateModified:2020-01-31T00:00:00Z
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      headline:mTOR at the nexus of nutrition, growth, ageing and disease
      description:The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. The mTOR pathway integrates diverse environmental cues to control biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing, and is thus a promising target for pharmacological intervention.
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Social Networks {👍}(2)

External Links {🔗}(1109)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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