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mTOR at the nexus of nutrition, growth, ageing and disease | Nature Reviews Molecular Cell Biology
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The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. The mTOR pathway integrates diverse environmental cues to control biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing, and is thus a promising target for pharmacological intervention.
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pubmed, article, google, scholar, cas, central, cell, mtorc, mtor, biol, nature, complex, signaling, rapamycin, mol, pathway, science, kinase, autophagy, protein, activation, regulation, phosphorylation, nat, amino, growth, cancer, regulates, sabatini, target, mammalian, chem, study, tsc, sci, acid, activity, tor, tumor, mice, cells, genes, function, signalling, synthesis, control, disease, factor, inhibition, dev,
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activating α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid permissions reprints privacy policy cytosol-open state nature portfolio journals scientific advisory board editing middle-aged mice ulk1–atg13–fip200 complex required advertising nature portfolio integrative cancer research mtor/s6k/4e-bp signaling yy1–pgc-1α transcriptional complex social media national library medical research brain-derived neurotrophic factor mediate cell-type-specific repression g1-arresting rapamycin–receptor complex biomedical research amino-acid-sensing pathway upstream amino-acid-replete conditions lipid-activated transcription factor foxo1–pgc-1α interaction discussed article content ubp3p/bre5p ubiquitin protease dox-loaded sio2 nanoparticles tumor-promoting phorbol esters atp-competitive catalytic inhibitor carboxy-terminal activation domain birt–hogg–dube syndrome golgi–lysosome contact site gtpase-activating protein complex elegans larval development female c57bl/6j mice author information authors amino acid-dependent activation pi3k/akt/mtor axis immuno-electron microscopy study rag gtpase-dependent manner nutrient-dependent mtorc1 association feedback-dependent biphasic regulation insulin-regulated hepatic gluconeogenesis mtor-regulated phosphoproteome reveals rapid antidepressant effects igf-1–akt–mtor pathways eif-4e bp1 phosphorylation phosphoinositide 3-kinase/akt pathway tumor suppressor complex
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- Rapamycin and Alzheimer’s disease: time for a clinical trial?
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