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Title[redir]:
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice - PMC
Description:
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruit flies1–5. However, whether inhibition of mTOR signalling can extend life in a mammalian ...
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Keywords {🔍}
mice, rapamycin, doi, lifespan, control, days, age, google, scholar, pubmed, females, males, sites, survival, test, pmc, life, controls, tor, effects, supplementary, male, ageing, figure, fed, female, rapa, article, pathway, effect, rapamycintreated, tjl, aging, mtor, mouse, data, table, percentile, nlm, genetically, feeding, cell, increase, interventions, diet, significant, free, signaling, site, heterogeneous,
Topics {✒️}
phosphoinositide 3-kinase/akt/mammalian target postpone strain-specific diseases12–14 short-lived model organisms gov/researchinformation/scientificresources/interventionstestingprogram log-rank test rejected site-specific calculations documented avoid genotype-specific effects nutrient/stress sensing pathways pmc beta search intervention decelerates age-dependent lower mortality prior effective anti-ageing intervention supplementary table s1 log-rank calculations rapamycin-fed mice received p-values represent results log-rank test supplementary table s2 supplementary materials included genetically heterogeneous mice15–17 genetically heterogeneous population15 ribosomal protein s6 greatly reduces fecundity license information pmcid wild strain alleles visceral fat pads visceral adipose tissue reduced tor function rapamycin-treated mice compared supplementary material anti-neoplastic activities anti-neoplastic effects25 insulin signaling pathway genetically heterogeneous mice united states government final edited form diseases rise rapidly food preparation process p38 mapk signaling protein-dye binding search log anti-aging interventions supplemental table s2 anti-ageing interventions fed similar diets nia grants ag022303 exp biol med tor pathway interacts tor signaling pathway joint life table19
Questions {❓}
- See commentary "Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?
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