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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

autophagy, doi, lifespan, animals, dietary, restriction, bec, mutants, rnai, elegans, scholar, pubmed, google, data, daf, figure, required, vps, longevity, inhibition, tor, rab, table, protein, adulthood, control, number, bacteria, pha, pmc, genes, cell, analysis, wildtype, shown, eat, additional, extension, article, response, cells, ppt, caenorhabditis, free, puncta, subjected, found, increased, pathway, eatad,

Topics {✒️}

long-lived insulin/igf-1-pathway mutants vacuolar protein atg8/map-lc3 bacteria-supplemented s-basal medium daf-2 insulin/igf-1-receptor mutants daf-2/insulin/igf receptor mutants insulin/igf-1-pathway mutants require long-lived hormone-pathway mutants complete s-basal medium forkhead-family transcription factor ins/igf-1 signalling pathway hnf-3/forkhead family member pmc beta search gene-specific rnai-bacterial plates tor-binding partner raptor purely post-translational mechanisms petroff-hausser counting chamber autophagic gene atg6/beclin1/bec-1 ribosomal-protein s6 kinase eif-4g/ifg-1 mutations daf-16/foxo transcription factor transcription factor daf-16/foxo insulin/igf-1 signaling pha-4/foxa transcription factors wild-type animals derived insulin/igf-1 pathway n2 wild-type animals gfp-positive punctate areas orfeome-based rnai library yielding similar results anti-ageing food restriction wild-type l3 animals autophagy requires pha-4/foxa insulin signaling pathway wild-type animals subjected cholesterol-dependent endocytosis pathway license information pmcid daf-2/insulin/igf-1 bec-1 [atg6/vps30/beclin1] shorten wild-type lifespan dietary-restriction fluorimetric profile long-lived animals subjected publisher site pdf long-lived daf-15 heterozygotes prevent s6-kinase/rsks-1 robust dietary-restriction phenotype large double-membrane vesicles gfp-labeled autophagic vesicles pha-4 rnai-bacteria compared cell-protective longevity proteins feeding bec-1 rnai-bacteria

Questions {❓}

• How might dietary restriction induce autophagy?
• Is autophagy required for the long lifespan induced by dietary restriction?
• Is it possible that this interpretation is incorrect, and that bec-1 and vps-34 actually have different functions in the animal that are required for longevity?
• Thus, these findings raise an interesting question: If protein synthesis falls in response to dietary restriction, and the lifespan extension produced by inhibiting protein synthesis does not involve autophagy, why is the lifespan extension produced by dietary restriction dependent on autophagy genes?
• What other functions could bec-1 and vps-34 have?
• Why are transcription factors as well as autophagy required for lifespan extension in daf-2 mutants?

Social Networks {👍}(6)

• https://twitter.com/ncbi
• https://www.facebook.com/ncbi.nlm
• https://www.linkedin.com/company/ncbinlm
• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

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