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We began analyzing https://www.nature.com/articles/nrc1877, but it redirected us to https://www.nature.com/articles/nrc1877. The analysis below is for the second page.

Title[redir]:
Fibroblasts in cancer | Nature Reviews Cancer
Description:
Fibroblasts are an important component of the tumour microenvironment. They become activated in tumours, as they do in healing wounds. Here, their roles in tumour initiation, progression and metastasis are reviewed. Tumours are known as wounds that do not heal β€” this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.

Matching Content Categories {πŸ“š}

  • Education
  • Science
  • Health & Fitness

Content Management System {πŸ“}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {πŸ’Έ}

We're unsure how the site profits.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org might be cashing in, but we can't detect the method they're using.

Keywords {πŸ”}

pubmed, google, scholar, cas, article, cancer, cells, fibroblasts, cell, nature, central, human, breast, growth, tumor, res, fibrosis, role, matrix, stromal, factor, progression, epithelial, tissue, fibroblast, rev, myofibroblasts, renal, usa, mammary, angiogenesis, access, sci, endothelial, extracellular, carcinoma, tumour, stroma, collagen, natl, protein, int, kalluri, cafs, vascular, biol, proc, acad, development, normal,

Topics {βœ’οΈ}

nature portfolio permissions reprints privacy policy twofold-reduced bone-marrow cellularity advertising cleared-fat-pad transplantation system express Ξ±-smooth-muscle actin transforming growth factor-Ξ²1 hgf-mediated signaling networks ddr2-regulated arginase activity bone-marrow-derived myofibroblasts contribute platelet-derived growth factor nature rev nature genet Ξ±-smooth muscle actin Ξ±-smooth-muscle actin autocrine migration-stimulating factor rsv-mediated tumor formation nature med author information authors cancer-induced stromal reaction cytokine-treated human fibroblasts social media conditioned media nature 362 nature 420 nature 339 nature 432 nature vascular permeability factor invasive bladder cancer intermediate-sized filaments distinguished elevated sdf-1/cxcl12 secretion springerlink instant access mammary gland development personal data permissions breast cancer development vpf/vegf-expressing tumors fsp1-positive cells leads vegf promoter activity author correspondence data protection maintaining gap junctions cleared fat pad process-related cafs fibroblast-specific protein monocyte secretory protein experimental melanoma metastasis human breast carcinomas

Questions {❓}

  • TGF-Ξ² antagonists: why suppress a tumor suppressor?

Schema {πŸ—ΊοΈ}

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         description:Fibroblasts are an important component of the tumour microenvironment. They become activated in tumours, as they do in healing wounds. Here, their roles in tumour initiation, progression and metastasis are reviewed. Tumours are known as wounds that do not heal Ҁ” this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
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