We are analyzing https://link.springer.com/article/10.1007/s10549-004-1424-7.

Title:
Genomic patterns of allelic imbalance in disease free tissue adjacent to primary breast carcinomas | Breast Cancer Research and Treatment
Description:
Mammary stroma plays an important role in facilitating the neoplastic transformation of epithelial cells, modulating integrity of the extracellular matrix, and maintaining genomic stability, but molecular mechanisms by which stroma affects epithelial structure and function are not well-defined. We used laser-assisted microdissection of paraffin-embedded breast tissues from 30 patients with breast disease and a panel of 52 microsatellite markers defining 26 chromosomal regions to characterize genomic patterns of allelic imbalance (AI) in disease-free tissue adjacent to sites of breast disease and to define genomic regions that may contain genes associated with early carcinogenic processes. The mean frequency of AI in histologically normal tissue adjacent to the primary carcinomas (15.4) was significantly higher than that in distant tissue from the same breast (3.7). The pattern of AI across all chromosomal regions differed between the adjacent tissue and primary tumor in every case. Unique AI events, observed only in tumor (15 of informative markers) or only in adjacent cells (10 of informative markers), were far more common than AI events shared between tumor and adjacent cells (~ 4). Levels of AI characteristic of advanced invasive carcinomas were already present in non-invasive ductal carcinomas in situ, and appreciable levels of AI were observed in adjacent non-neoplastic tissue at all pathological stages. Chromosome 11p15.1 showed significantly higher levels of AI in adjacent cells (p < 0.01), suggesting that this region may harbor genes involved in breast cancer development and progression. Our data indicate that genomic instability may be inherently greater in disease-free tissue close to developing tumors, which may have important implications for defining surgical margins and predicting recurrence.
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Keywords {🔍}

google, scholar, breast, cancer, ellsworth, tissue, res, article, adjacent, genetic, loss, genomic, carcinomas, tumor, cells, heterozygosity, gene, human, research, imbalance, normal, cell, allelic, shriver, stroma, access, privacy, cookies, content, search, disease, mammary, regions, genes, chromosome, progression, genet, alterations, carcinoma, pathol, oncogene, data, publish, primary, love, deyarmin, lubert, epithelial, levels, ductal,

Topics {✒️}

pin2/trf1–interacting protein pinx1 real-world clinical application tumour-adjacent normal tissue month download article/chapter tlsty td disease-free tissue close paraffin-embedded breast tissues pre-invasive breast disease disease-free tissue adjacent case-control study confirms microsatellite-based cancer detection tumour-microenvironment interactions genome-wide search breast cancers privacy choices/manage cookies tumor heterogeneity windber research institute artificial intelligence algorithm related subjects define genomic regions squamous epithelial carcinogenesis chromosomal regions differed full article pdf normal mammary epithelium human breast cancer human chromosome 8p22 gene expression profiles defining surgical margins maintaining genomic stability characterize genomic patterns genomic instability comparative genomic hybridization usual ductal hyperplasia human breast carcinomas chromosomal arm 8p invasive ductal carcinomas �clinging ductal carcinoma normal tissue adjacent breast cancer development breast cancer detection breast cancer reveal breast cancer progression a'hern rp heterozygosity stroma access harbor genes involved european economic area early carcinogenic processes contribute oncogenic signals interphase cytogenetic study de las morenas

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         headline:Genomic patterns of allelic imbalance in disease free tissue adjacent to primary breast carcinomas
         description:Mammary stroma plays an important role in facilitating the neoplastic transformation of epithelial cells, modulating integrity of the extracellular matrix, and maintaining genomic stability, but molecular mechanisms by which stroma affects epithelial structure and function are not well-defined. We used laser-assisted microdissection of paraffin-embedded breast tissues from 30 patients with breast disease and a panel of 52 microsatellite markers defining 26 chromosomal regions to characterize genomic patterns of allelic imbalance (AI) in disease-free tissue adjacent to sites of breast disease and to define genomic regions that may contain genes associated with early carcinogenic processes. The mean frequency of AI in histologically normal tissue adjacent to the primary carcinomas (15.4) was significantly higher than that in distant tissue from the same breast (3.7). The pattern of AI across all chromosomal regions differed between the adjacent tissue and primary tumor in every case. Unique AI events, observed only in tumor (15 of informative markers) or only in adjacent cells (10 of informative markers), were far more common than AI events shared between tumor and adjacent cells (~ 4). Levels of AI characteristic of advanced invasive carcinomas were already present in non-invasive ductal carcinomas in situ, and appreciable levels of AI were observed in adjacent non-neoplastic tissue at all pathological stages. Chromosome 11p15.1 showed significantly higher levels of AI in adjacent cells (p < 0.01), suggesting that this region may harbor genes involved in breast cancer development and progression. Our data indicate that genomic instability may be inherently greater in disease-free tissue close to developing tumors, which may have important implications for defining surgical margins and predicting recurrence.
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      headline:Genomic patterns of allelic imbalance in disease free tissue adjacent to primary breast carcinomas
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      dateModified:
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      pageEnd:139
      sameAs:https://doi.org/10.1007/s10549-004-1424-7
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         allelic imbalance
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         field cancerization
         loss of heterozygosity
         stroma
         Oncology
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