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  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
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We began analyzing https://www.nature.com/articles/nm.2454, but it redirected us to https://www.nature.com/articles/nm.2454. The analysis below is for the second page.

Title[redir]:
Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes | Nature Medicine
Description:
By implementing the conditions for orthotopic implantation of different types of human breast tumors, the authors have created a publicly available bank of new mouse models that more faithfully recreate individual tumor properties and provide individualized information about tumor behavior and prognosis. Development and preclinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis in the form of transplantable tumors derived directly from individuals undergoing treatment for breast cancer. These tumor grafts illustrate the diversity of human breast cancer and maintain essential features of the original tumors, including metastasis to specific sites. Co-engraftment of primary human mesenchymal stem cells maintains phenotypic stability of the grafts and increases tumor growth by promoting angiogenesis. We also report that tumor engraftment is a prognostic indicator of disease outcome for women with newly diagnosed breast cancer; orthotopic breast tumor grafting is a step toward individualized models for tumor growth, metastasis and prognosis. This bank of tumor grafts also serves as a publicly available resource for new models in which to study the biology of breast cancer.

Matching Content Categories {πŸ“š}

  • Education
  • Health & Fitness
  • Science

Content Management System {πŸ“}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of doi.org audience?

πŸ™οΈ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 96,105,781 visitors per month in the current month.

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How Does Doi.org Make Money? {πŸ’Έ}

We don’t know how the website earns money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {πŸ”}

cancer, pubmed, article, breast, google, scholar, cas, nature, tumor, central, metastasis, models, cells, utah, human, stem, access, usa, institute, welm, cell, huntsman, growth, university, supplementary, content, data, research, salt, lake, city, cookies, disease, nat, mouse, gene, res, department, privacy, information, medicine, grafts, pathology, development, preclinical, tumors, open, clin, alw, journal,

Topics {βœ’οΈ}

nature portfolio permissions reprints privacy policy advertising cancer research social media nod/scid-related strains author information authors nature 464 nature 456 nature 449 nature 406 nature triple-negative breast cancer node-negative breast cancer anticancer drug development author correspondence nod/scid/Ξ³ springerlink instant access permissions human breast cancer primary xenograft model mesenchymal stem cells regional human breast tumors human breast tumours breast cancer metastasis breast cancer based cancer stem cells breast tumor subtypes efficient tumour formation tumor grafts derived personal data huntsman cancer foundation breast cancer res breast tumor growth huntsman cancer institute privacy mammary stem cells cancer gene discovery development competing financial interests gene expression imposed gene-expression signature gene expression patterns cervical cancer enables data protection medical oncology division explore content subscription content

Questions {❓}

  • Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?
  • Models of breast cancer: quo vadis, animal modeling?
  • Triple-negative breast cancer: disease entity or title of convenience?

Schema {πŸ—ΊοΈ}

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         headline:Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
         description:By implementing the conditions for orthotopic implantation of different types of human breast tumors, the authors have created a publicly available bank of new mouse models that more faithfully recreate individual tumor properties and provide individualized information about tumor behavior and prognosis. Development and preclinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis in the form of transplantable tumors derived directly from individuals undergoing treatment for breast cancer. These tumor grafts illustrate the diversity of human breast cancer and maintain essential features of the original tumors, including metastasis to specific sites. Co-engraftment of primary human mesenchymal stem cells maintains phenotypic stability of the grafts and increases tumor growth by promoting angiogenesis. We also report that tumor engraftment is a prognostic indicator of disease outcome for women with newly diagnosed breast cancer; orthotopic breast tumor grafting is a step toward individualized models for tumor growth, metastasis and prognosis. This bank of tumor grafts also serves as a publicly available resource for new models in which to study the biology of breast cancer.
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      headline:Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
      description:By implementing the conditions for orthotopic implantation of different types of human breast tumors, the authors have created a publicly available bank of new mouse models that more faithfully recreate individual tumor properties and provide individualized information about tumor behavior and prognosis. Development and preclinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis in the form of transplantable tumors derived directly from individuals undergoing treatment for breast cancer. These tumor grafts illustrate the diversity of human breast cancer and maintain essential features of the original tumors, including metastasis to specific sites. Co-engraftment of primary human mesenchymal stem cells maintains phenotypic stability of the grafts and increases tumor growth by promoting angiogenesis. We also report that tumor engraftment is a prognostic indicator of disease outcome for women with newly diagnosed breast cancer; orthotopic breast tumor grafting is a step toward individualized models for tumor growth, metastasis and prognosis. This bank of tumor grafts also serves as a publicly available resource for new models in which to study the biology of breast cancer.
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            address:
               name:The Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Rachel Factor
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Pathology, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Cindy Matsen
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Brett A Milash
      affiliation:
            name:Bioinformatics Core Facility, Huntsman Cancer Institute, University of Utah Health Sciences Center
            address:
               name:Bioinformatics Core Facility, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Edward Nelson
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Leigh Neumayer
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:R Lor Randall
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Inge J Stijleman
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Pathology, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Bryan E Welm
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      name:Alana L Welm
      affiliation:
            name:Huntsman Cancer Institute, University of Utah
            address:
               name:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Pathology, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:The Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, USA
      name:Department of Internal Medicine, Medical Oncology Division, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:The Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, USA
      name:Department of Pathology, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Bioinformatics Core Facility, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, USA
      name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Pathology, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
      name:Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
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